Norikazu Matsutomo    Department   Kawasaki University of Medical Welfare  ,    Position   Associate Professor with Special Assignment
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Combination of compressed sensing-based iterative reconstruction and offset acquisition for I-123 FP-CIT SPECT: a simulation study.
Journal	Formal name：Asia Oceania journal of nuclear medicine & biology Abbreviation：Asia Ocean J Nucl Med Biol ISSN code：23225718/23225718
Domestic / Foregin	Foregin
Volume, Issue, Page	10(2),pp.117-125
Author and coauthor	Norikazu Matsutomo, Takeyuki Hashimoto, Mitsuha Fukami, Tomoaki Yamamoto
Publication date	2022
Summary	OBJECTIVES:The purpose of this study was to validate undersampled single-photon emission computed tomography (SPECT) imaging using a combination of compressed sensing (CS) iterative reconstruction (CS-IR) and offset acquisition.METHODS:Three types of numerical phantoms were used to evaluate image quality and quantification derived from CS with offset acquisition. SPECT images were reconstructed using filtered back-projection (FBP), maximum likelihood-expectation maximization (ML-EM), CS-IR, and CS-IR with offset acquisition. The efficacy of CS-IR with offset acquisition was examined in terms of spatial resolution, aspect ratio (ASR), activity concentration linearity, contrast, percent coefficient of variation (%CV), and specific binding ratio (SBR).RESULTS:The full widths at half maximum remained unchanged as the number of projections decreased in CS-IR with offset acquisition. Changes in ASRs and linearities of count density were observed for ML-EM and CS-IR from undersampled projections. The %CV obtained by CS-IR with offset acquisition was substantially lower than that obtained by ML-EM and CS-IR. There were no significant differences between the %CVs obtained from 60 projections by CS-IR with offset acquisition and from 120 projections by FBP. Although the SBRs for CS-IR with offset acquisition tended to be slightly lower than for FBP, the SBRs for CS-IR with offset acquisition did not change with the number of projections.CONCLUSIONS:CS-IR with offset acquisition can provide good image quality and quantification compared with a commonly used SPECT reconstruction method, especially from undersampled projection data. Our proposed method could shorten overall SPECT acquisition times, which would benefit patients and enable quantification with dynamic SPECT acquisitions.
DOI	10.22038/AOJNMB.2021.59585.1417
PMID	35800416