Norikazu Matsutomo
   Department   Kawasaki University of Medical Welfare  ,
   Position   Associate Professor with Special Assignment
Article types 原著
Language English
Peer review Peer reviewed
Title Optimization of scatter estimation window setting for quantitative analysis in 111In-pentetreotide single photon emission computed tomography imaging.
Journal Formal name：Hellenic journal of nuclear medicine
Abbreviation：Hell J Nucl Med
ISSN code：17905427/17905427
Domestic / ForeginForegin
Volume, Issue, Page 23(3),pp.223-228
Author and coauthor Mizuho Hishikawa, Norikazu Matsutomo, Tomoaki Yamamoto
Publication date 2020
Summary OBJECTIVE:The aim of this study was to validate the optimal scatter correction method and scatter estimation window setting in terms of image quality and quantitative accuracy for quantitative indium-111 (111In)-pentetreotide SPECT imaging.MATERIALS AND METHODS:We used a positron emission tomography/computed tomography (PET/CT) phantom to validate image quality and quantitative accuracy, and the SPECT images were acquired by the multi-energy window (MEW) method. The scatter estimation was performed using four kinds of energy windows (MEW1, MEW2, MEW3, and MEW4). Scatter correction was also performed using a dual-energy window (DEW) for comparison with MEWs. Image quality was assessed using percent contrast (% contrast) and background variability, and quantitative accuracy was assessed using the mean standardized uptake value (SUVmean) with hot spheres.RESULTS:In the quantification, all MEW settings approached the theoretical SUVmean (MEW1, 0.99±0.06; MEW2, 0.99±0.05; MEW3, 1.00±0.08; MEW4, 0.97±0.12) in contrast to DEW (0.88±0.05). The SUVmean value for scatter correction of both photopeaks for a 28 mm sphere showed the smallest difference from the theoretical value.CONCLUSION:The scatter correction method that gave optimal image quality and quantitative accuracy was MEW3 with two 20% energy windows (one over each photopeak) and four adjacent 3% scatter estimation windows (one on each side of the two photopeaks).
DOI 10.1967/s002449912200
PMID 33306751