Norikazu Matsutomo
   Department   Kawasaki University of Medical Welfare  ,
   Position   Associate Professor with Special Assignment
Article types 原著
Language English
Peer review Peer reviewed
Title Validation of a calibration method using the cross-calibration factor and system planar sensitivity in quantitative single-photon emission computed tomography imaging.
Journal Formal name：Radiological physics and technology
Abbreviation：Radiol Phys Technol
ISSN code：18650341/18650333
Domestic / ForeginDomestic
Volume, Issue, Page 10(4),pp.439-445
Author and coauthor Norikazu Matsutomo, Saki Matsumoto, Tomoaki Yamamoto, Eisuke Sato
Publication date 2017/12
Summary The present study aimed to validate the absolute quantitative accuracy of a calibration method for single-photon emission computed tomography (SPECT) using cross-calibration factor (CCF)- and system sensitivity-based calibration methods. The CCF obtained with different reconstruction parameters was evaluated using a cylindrical phantom (diameter 20 cm, height 20 cm). SPECT images were acquired with a positron emission tomography/computed tomography (CT) phantom. Subsequently, they were reconstructed by using ordered subset expectation maximization with resolution recovery, scatter, and CT-based attenuation correction. All reconstructed SPECT counts were converted to activity concentrations based on the CCF and system planar sensitivity. We placed 12 circular regions of interest, 37 mm in diameter, on the phantom background, and the converted activity concentration and relative measurement error were assessed. The CCF obtained using a cylindrical phantom was affected by the iterative update number and post-smoothing filter function. The activity concentration calibrated using the CCF showed over- and underestimation. However, the activity concentration obtained from the system planar sensitivity was similar to that gained using the phantom. The values obtained using the system planar sensitivity were within 10% of the activity concentrations obtained with the phantom. These findings demonstrated that the calibration method using system planar sensitivity provides accurate quantification within 10% of the true activity concentration. Further clinical examination is required to validate the present results.
DOI 10.1007/s12194-017-0416-3
PMID 28822095