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Shunji Endo
Department Kawasaki Medical School Kawasaki Medical School, Department of Digestive Surgery, Position Associate Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Prognostic Factors for Para-aortic Lymph Node Dissection After Neoadjuvant Chemotherapy for Gastric Cancer. |
| Journal | Formal name：Anticancer research Abbreviation：Anticancer Res ISSN code：17917530/02507005 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 40(4),pp.2351-2357 |
| Author and coauthor | Endo Shunji, Ikenaga Masakazu, Yamada Terumasa, Tamura Shigeyuki, Sasaki Y O |
| Authorship | Lead author |
| Publication date | 2020/04 |
| Summary | BACKGROUND/AIM:The prognosis of gastric cancer with para-aortic or bulky lymph node metastases is poor, but the JCOG 0405 study showed relatively good outcomes of neoadjuvant chemotherapy and gastrectomy with para-aortic lymph node dissection. We investigated the prognostic factors for this treatment.PATIENTS AND METHODS:Twenty patients who underwent gastrectomy and para-aortic lymph node dissection after chemotherapy were enrolled from two institutions. The prognostic factors for overall survival were retrospectively analysed using Cox's proportional hazard models.RESULTS:The univariate analyses revealed that ypN (3/0-2, p=0.001), ypM1 (para-aortic LYM) (yes/no, p=0.03), histological response (Grade0-1b/2-3, p=0.02), and adjuvant chemotherapy (no/yes, p=0.02) were significant prognostic factors, whereas multivariate analysis revealed ypN and absence of adjuvant chemotherapy to be independent prognostic factors.CONCLUSION:Posttreatment nodal status may be the best surrogate marker for gastric cancer with gastrectomy and para-aortic lymph node dissection after neoadjuvant chemotherapy. Adjuvant chemotherapy seems to be essential to improve survival. |
| DOI | 10.21873/anticanres.14203 |
| PMID | 32234937 |