Dai Une    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Cardiovascular Surgery,    Position   Professor
Article types	症例報告
Language	English
Peer review	Peer reviewed
Title	Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis.
Journal	Formal name：The journal of physiological sciences : JPS Abbreviation：J Physiol Sci ISSN code：18806562/18806546
Domestic / Foregin	Domestic
Volume, Issue, Page	66(3),pp.249-55
Author and coauthor	Shuji Shimizu, Toru Kawada, Dai Une, Masafumi Fukumitsu, Michael James Turner, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi
Publication date	2016/05
Summary	Cavopulmonary assist (CPA) for failing Fontan patients remains a challenging issue in the clinical setting. To evaluate the effectiveness of a partial CPA from the inferior vena cava (IVC) to the pulmonary artery (PA), we performed a theoretical analysis using a computational model of the Fontan circulation. Cardiac chambers and vascular systems were described as the time-varying elastance model and the modified three-element Windkessel model, respectively. A rotational pump described as a non-linear function was inserted between the IVC and the PA. When pulmonary vascular resistance index varied from 2.1 to 5.9 Wood units m(2), the partial CPA maintained cardiac index as efficiently as total CPA and markedly reduced the IVC pressure compared with total CPA. However, the partial CPA increased the superior vena cava pressure substantially. The modification from total to partial CPA is potentially an effective alternative in failing Fontan patients suffering from high IVC pressure.
DOI	10.1007/s12576-015-0422-3
PMID	26546008