Dai Une    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Cardiovascular Surgery,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation: a theoretical analysis.
Journal	Formal name：The journal of physiological sciences : JPS Abbreviation：J Physiol Sci ISSN code：18806562/18806546
Domestic / Foregin	Domestic
Volume, Issue, Page	61(6),pp.457-65
Author and coauthor	Shuji Shimizu, Dai Une, Toshiaki Shishido, Atsunori Kamiya, Toru Kawada, Shunji Sano, Masaru Sugimachi
Publication date	2011/11
Summary	When the Norwood procedure is conducted for the hypoplastic left heart syndrome using a non-valved right ventricle (RV) to pulmonary artery (PA) shunt, diastolic regurgitation from PA to RV may have an adverse effect on postoperative hemodynamics. In this study, we examined the impact of the diastolic regurgitation on ventricular energetics by computational analysis using a combination of a time-varying elastance chamber model and a modified three-element Windkessel vascular model. This study revealed that use of the valved or non-valved RV-PA shunt eliminated pulmonary over-circulation which was observed when using the systemic to pulmonary artery shunt (modified Blalock-Taussig shunt). Although the valved RV-PA shunt improved pulmonary blood supply and consequently increased pulmonary artery flow and oxygen saturation compared to the non-valved RV-PA shunt, the non-valved RV-PA shunt improved ventricular energetics in spite of the presence of PA to RV regurgitation.
DOI	10.1007/s12576-011-0166-7
PMID	21830144