Dai Une    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Cardiovascular Surgery,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis.
Journal	Formal name：The journal of physiological sciences : JPS Abbreviation：J Physiol Sci ISSN code：18806562/18806546
Domestic / Foregin	Domestic
Volume, Issue, Page	60(3),pp.205-12
Author and coauthor	Shuji Shimizu, Toshiaki Shishido, Dai Une, Atsunori Kamiya, Toru Kawada, Shunji Sano, Masaru Sugimachi
Publication date	2010/05
Summary	One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumped-parameter state-variable equations. We varied the RV stiffness constant (B (RV)) to simulate the various RV hypoplasia, and estimated hemodynamics for a given B (RV). With B (RV) < 150% of normal, cardiac output was the largest in 2VR. With B (RV) > 150%, cardiac output became larger in 1.5VR than in 2VR. With B (RV) > 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.
DOI	10.1007/s12576-010-0086-y
PMID	20131025