スギヤマ　ヒトシ   杉山　斉    所属   川崎医療短期大学  教育部 医療介護福祉学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Aetiology of acute/subacute nephritic syndrome: results from kidney biopsy registries in Japan and Europe.
掲載誌名	正式名：BMC Nephrology 略　 称：BMC Nephrol
掲載区分	国外
巻・号・頁	26(1),pp.625
国際共著	国際共著
著者・共著者	Weiner M, Sugiyama H, Kaname S, Skrunes R, Prenner A, Crnogorac M, Geddes C, Türkmen K, Galesic K, Rosenkranz AR, Suzuki Y, Fujimoto S, Segelmark M.
担当区分	2nd著者
発行年月	2025/11/06
概要	Background: The combination of hematuria, proteinuria and a reduced glomerular filtration rate (GFR) in patients with no previous diagnosis of chronic kidney disease is widely considered a strong indication for kidney biopsy. This study aimed to compare the frequencies of diseases leading to this symptom constellation, and to explore differences related to age and sex using data from kidney biopsy registries in Europe and Japan. Methods: Data were retrieved from national or regional kidney biopsy registries in Japan, Sweden, Norway, Scotland, Austria, Croatia and Turkey from January 1, 2007, to December 31, 2019. Patients were included if the indication for kidney biopsy was acute/subacute nephritic syndrome, which was defined as a combination of hematuria, proteinuria and reduced GFR in a patient without a prior diagnosis of chronic kidney disease. Demographic, clinical and laboratory data were collected at the time of kidney biopsy. Results: A total of 1023 patients from Europe and 2477 from Japan were included in the study. The primary cause of acute/subacute nephritic syndrome in both regions was ANCA-associated vasculitis, followed by IgA nephropathy/vasculitis and acute interstitial nephritis. The estimated GFR was higher in Europe than in Japan, at 24 and 20 ml/min/1,73 m2, respectively. The median age was 10 years younger in European patients than in Japanese patients. Conclusions: The most common underlying causes of acute/subacute nephritic syndrome are ANCA-associated vasculitis, IgA nephropathy/vasculitis and acute interstitial nephritis. This study highlights both similarities and differences in the spectrum of underlying diagnoses and clinical presentations across ages, sexes, and geographical regions in patients presenting with acute/subacute nephritic syndrome.
DOI	10.1186/s12882-025-04582-6
PMID	41199173