コンド　マユミ   Mayumi Kondo   近土　真由美    所属   川崎医療福祉大学  医療技術学部 臨床工学科    職種   講師
論文種別	研究論文（学術雑誌）
言語種別	英語
査読の有無	査読あり
表題	Molecular evolutionary analyses of the fusion protein gene in human respirovirus 1.
掲載誌名	正式名：Virus research 略　 称：Virus Res ISSNコード：18727492/01681702
掲載区分	国外
巻・号・頁	333,pp.199142
著者・共著者	Tomoko Takahashi, Mao Akagawa, Ryusuke Kimura, Mitsuru Sada, Tatsuya Shirai, Kaori Okayama, Yuriko Hayashi, Mayumi Kondo, Makoto Takeda, Akihide Ryo, Hirokazu Kimura
発行年月	2023/08
概要	Few evolutionary studies of the human respiratory virus (HRV) have been conducted, but most of them have focused on HRV3. In this study, the full-length fusion (F) genes in HRV1 strains collected from various countries were subjected to time-scaled phylogenetic, genome population size, and selective pressure analyses. Antigenicity analysis was performed on the F protein. The time-scaled phylogenetic tree using the Bayesian Markov Chain Monte Carlo method estimated that the common ancestor of the HRV1 F gene diverged in 1957 and eventually formed three lineages. Phylodynamic analyses showed that the genome population size of the F gene has doubled over approximately 80 years. Phylogenetic distances between the strains were short (< 0.02). No positive selection sites were detected for the F protein, whereas many negative selection sites were identified. Almost all conformational epitopes of the F protein, except one in each monomer, did not correspond to the neutralising antibody (NT-Ab) binding sites. These results suggest that the HRV1 F gene has constantly evolved over many years, infecting humans, while the gene may be relatively conserved. Mismatches between computationally predicted epitopes and NT-Ab binding sites may be partially responsible for HRV1 reinfection and other viruses such as HRV3 and respiratory syncytial virus.
DOI	10.1016/j.virusres.2023.199142
PMID	37270034
researchmap用URL	https://doi.org/10.1016/j.virusres.2023.199142