スズキ　ケイタ   Keita Suzuki   鈴木　啓太    所属   川崎医療福祉大学  リハビリテーション学部 理学療法学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Association of oral frailty and gut microbiota with hypertension: cross-sectional results in the Shika study.
掲載誌名	正式名：Frontiers of medicine 略　 称：Front Med ISSNコード：20950225/20950217
掲載区分	国外
巻・号・頁	19,pp.1036-1048
著者・共著者	Fumihiko Suzuki, Ren Mizoguchi, Shigehiro Karashima, Yasuo Ikagawa, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Thao Thi Thu Nguyen, Atsushi Asai, Koji Katano, Tomoko Kasahara, Kuniko Sato, Masaharu Nakamura, Yukari Shimizu, Aki Shibata, Keita Suzuki, Takayuki Kannon, Noriyoshi Ogino, Hirohito Tsuboi, Atsushi Tajima, Shigefumi Okamoto, Hiroyuki Nakamura
発行年月	2025/12
概要	Although recent studies have reported the association between toxins produced by certain gut microbiota and elevated blood pressure, the relationship between oral frailty (OF) and gut microbiota has rarely been investigated. The purpose of this study was to epidemiologically investigate the relationship between the combination of OF and specific gut microbiota on hypertension in the residents of Shika Town, Ishikawa Prefecture, Japan. A total of 322 residents aged ⩾ 50 years in Shika Town agreed to participate and met the criteria. The OF was evaluated difficulty in chewing and swallowing, oral dryness, number of remaining teeth, and frequency of tooth brushing. Blood pressure was measured using an automatic digital blood pressure meter. Next-generation sequencing was used to analyze the gut microbiota. A two-way analysis of covariance revealed a significant interaction between the two OF groups and the two hypertension groups on Megamonas. The binomial logistic regression analysis stratified by OF revealed a positive correlation between Megamonas and hypertension (OR 1.317; P = 0.023). This cross-sectional epidemiological study of the local residents revealed that the abundance of Megamonas in the OF group was significantly higher in the hypertension group than in the normotension group; however, no such relationship was observed in the non-OF group.
DOI	10.1007/s11684-025-1169-8
PMID	41454073