タナカ　リョウジロウ   Ryojiro Tanaka   田中　亮二郎    所属   川崎医科大学  医学部 臨床医学　小児科学    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Insignificant impact of VUR on the progression of CKD in children with CAKUT.
掲載誌名	正式名：Pediatric nephrology (Berlin, Germany) 略　 称：Pediatr Nephrol ISSNコード：1432198X/0931041X
掲載区分	国外
巻・号・頁	31(1),pp.105-12
著者・共著者	Kenji Ishikura, Osamu Uemura, Yuko Hamasaki, Hideo Nakai, Shuichi Ito, Ryoko Harada, Motoshi Hattori, Yasuo Ohashi, Ryojiro Tanaka, Koichi Nakanishi, Tetsuji Kaneko, Kazumoto Iijima, Masataka Honda,
発行年月	2016/01
概要	BACKGROUND:Vesicoureteral reflux (VUR) is associated with an increased risk of kidney disorders. It is unclear whether VUR is associated with progression from chronic kidney disease (CKD) to end-stage kidney disease (ESKD) in children with congenital anomalies of the kidney and urinary tract (CAKUT).METHODS:We conducted a 3-year follow-up survey of a cohort of 447 children with CKD (stage 3-5). Rates of and risk factors for progression to ESKD were determined using the Kaplan-Meier method and Cox regression respectively.RESULTS:Congenital anomaly of the kidney and urinary tract was the primary etiology in 278 out of 447 children; 118 (42.4 %) had a history of VUR at the start of the cohort study. There were significantly more boys than girls with VUR, whereas the proportions were similar in children without VUR. The types of urinary anomalies/complications of the two groups were significantly different. Three-year renal survival rates of the groups were not significantly different, irrespective of CKD stage. Age  < 2 years and age after puberty, stage 4 or 5 CKD, and heavy proteinuria, but not history of VUR, were significantly associated with progression to ESKD.CONCLUSIONS:History of VUR at the start of follow-up was not associated with the progression of stage 3-5 CKD in children with CAKUT.
DOI	10.1007/s00467-015-3196-1
PMID	26404649