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タナカ リョウジロウ
Ryojiro Tanaka
田中 亮二郎 所属 川崎医科大学 医学部 臨床医学 小児科学 職種 特任教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Spontaneous remission in children with IgA nephropathy. |
| 掲載誌名 | 正式名：Pediatric nephrology (Berlin, Germany) 略 称：Pediatr Nephrol ISSNコード：1432198X/0931041X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 28(1),pp.71-6 |
| 著者・共著者 | Yuko Shima, Koichi Nakanishi, Taketsugu Hama, Hironobu Mukaiyama, Hiroko Togawa, Mayumi Sako, Hiroshi Kaito, Kandai Nozu, Ryojiro Tanaka, Kazumoto Iijima, Norishige Yoshikawa |
| 発行年月 | 2013/01 |
| 概要 | BACKGROUND:Some patients with IgA nephropathy (IgAN) achieve spontaneous remission even when not receiving medication. However, details on such remissions remain unknown. The aim of our study was to clarify this information in the clinical setting of childhood IgAN with minor glomerular abnormalities or focal mesangial proliferation (MGA/FMP).METHODS:This study was a retrospective analysis of 96 children with MGA/FMP who did not receive medication from among the 555 patients with newly diagnosed childhood IgAN treated between January 1972 and December 2000. The Kaplan-Meier method and Cox proportional hazard model were used for the analysis.RESULTS:Of the 96 pediatric patients who did not receive medication, 57 (59.4 %) achieved spontaneous remission. The cumulative spontaneous remission rates among these patients were 57.5 and 77.4 % at 5 and 10 years, respectively, from onset. The mean time from onset to remission was 5.9 ± 0.4 years. Clinical and histological findings were similar between the remission and non-remission groups. Of the 57 patients with spontaneous remissions, ten (17.5 %) also developed a recurrence of urinary abnormalities. The cumulative recurrence-free rates were 79.9 and 67.9 % at 5 and 10 years, respectively, after remission.CONCLUSIONS:The spontaneous remission rate in childhood IgAN with MGA/FMP was higher than expected. Our results suggest that physicians should consider the potential for spontaneous remission and refrain from very aggressive treatment in IgAN patients with MGA/FMP. |
| DOI | 10.1007/s00467-012-2294-6 |
| PMID | 22940909 |