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タナカ リョウジロウ
Ryojiro Tanaka
田中 亮二郎 所属 川崎医科大学 医学部 臨床医学 小児科学 職種 特任教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognosis and pathological characteristics of five children with non-Shiga toxin-mediated hemolytic uremic syndrome. |
| 掲載誌名 | 正式名：Pediatrics international : official journal of the Japan Pediatric Society 略 称：Pediatr Int ISSNコード：13288067/13288067 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 49(2),pp.196-201 |
| 著者・共著者 | Ichiro Kamioka, Kandai Nozu, Teruo Fujita, Hiroshi Kaito, Ryojiro Tanaka, Kunihiko Yoshiya, Kazumoto Iijima, Koichi Nakanishi, Norishige Yoshikawa, Masafumi Matsuo |
| 発行年月 | 2007/04 |
| 概要 | BACKGROUND:The three major signs of hemolytic uremic syndrome (HUS) are hemolytic anemia, thrombopenia and acute renal failure. HUS is classified into Shiga toxin-mediated HUS (Stx-HUS) and non-Shiga toxin-mediated HUS (nStx-HUS). The prognosis of nStx-HUS is reported to be less favorable than that of Stx-HUS. Although the association between the prognosis and pathological characteristics of HUS have been reported such that the prognosis was considered to be poor for thrombotic microangiopathy (TMA) with predominant arterial involvement (arterial TMA), good for TMA with predominant glomerular involvement (glomerular TMA) and dependent on the extent of necrosis in cases of renal cortical necrosis, it is not yet clear whether pathological findings are also related to the renal prognosis of nStx-HUS cases. Therefore the purpose of the present paper was to analyze renal biopsy findings and prognosis for five children with nStx-HUS.METHODS:Clinical records of five cases of nStx-HUS among 74 cases of diagnosed HUS were reviewed, and information and data were summarized.RESULTS:Histological examination of the kidney led to the diagnosis of arterial TMA in three cases, and glomerular TMA and severe renal cortical necrosis in one case each. Analysis of the relationship between renal histological findings and the prognosis found that three patients with arterial TMA and one patient with severe renal cortical necrosis later developed end-stage renal failure while one patient with glomerular TMA has continued to show normal renal function.CONCLUSIONS:These findings indicate that pathological findings are closely related to the prognosis in cases of nStx-HUS. |
| DOI | 10.1111/j.1442-200X.2007.02352.x |
| PMID | 17445038 |