オクヤマ　ミチヒロ   Michihiro Okuyama   奥山　倫弘    所属   川崎医科大学  医学部 臨床医学　心臓血管外科学    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats.
掲載誌名	正式名：BioMed research international 略　 称：Biomed Res Int ISSNコード：23146141
掲載区分	国外
巻・号・頁	2015,pp.753210
著者・共著者	Masataka Hirata, Daiki Ousaka, Sadahiko Arai, Michihiro Okuyama, Suguru Tarui, Junko Kobayashi, Shingo Kasahara, Shunji Sano
発行年月	2015
概要	BACKGROUND:Congenital heart diseases often involve chronic pressure overload of the right ventricle (RV) which is a major cause of RV dysfunction. Pulmonary artery (PA) banding has been used to produce animal models of RV dysfunction. We have devised a new and easier method of constricting the PA and compared it directly with the partial ligation method.METHODS:Eight-week-old male Sprague-Dawley rats (240-260 g) were divided into three groups: sham operation, partial pulmonary artery ligation (PAL) procedure, and pulmonary artery half-closed clip (PAC) procedure. RV function and remodeling were determined by echocardiography and histomorphometry.RESULTS:Surgical mortality was significantly lower in the PAC group while echocardiography revealed significantly more signs of RV dysfunction. At the 8th week after surgery RV fibrosis rate was significantly higher in the PAC group.CONCLUSIONS:This procedure of pulmonary artery banding in rats is easier and more efficient than partial ligation.
DOI	10.1155/2015/753210
PMID	26504827