イハラ　トシコ   Toshiko Ito-Ihara   猪原　登志子    所属   川崎医科大学  医学部 応用医学　先端医療開発学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Myeloperoxidase-anti-neutrophil cytoplasmic antibody positivity and disease characteristics, treatment, and prognosis in eosinophilic granulomatosis with polyangiitis.
掲載誌名	正式名：Scandinavian journal of rheumatology 略　 称：Scand J Rheumatol ISSNコード：15027732/03009742
掲載区分	国外
巻・号・頁	55(2),pp.134-142
著者・共著者	S Fukui, K Ichinose, H Ide, T Uchida, T Shimizu, M Umeda, R Sumiyoshi, T Koga, S-Y Kawashiri, N Iwamoto, T Origuchi, S Omura, D Nakagomi, Y Abe, M Wada, N Takizawa, A Nomura, Y Kukida, N Kondo, Y Yamano, H Takagi, K Endo, S Hirata, N Azuma, T Takeuchi, K Kamada, R Yanai, Y Matsuo, Y Shimojima, R Nishioka, R Okazaki, T Takata, M Moriyama, A Takatani, Y Miyawaki, T Shirai, H Dobashi, T Ito, I Matsumoto, T Takada, T Ito-Ihara, T Kida, N Yajima, T Kawaguchi, Y Kawahito, A Kawakami
発行年月	2026/03
概要	OBJECTIVES:To evaluate the relationship between anti-neutrophil cytoplasmic antibody (ANCA) positivity and the disease characteristics, treatment, and prognosis of eosinophilic granulomatosis with polyangiitis (EGPA).METHOD:We conducted a retrospective cohort study of patients with new-onset or severely relapsing ANCA-associated vasculitis, enrolled in the J-CANVAS registry. The clinical characteristics at baseline, treatments, and prognoses of ANCA-positive and ANCA-negative patients were assessed.RESULTS:Three patients with positive proteinase-3 ANCA were excluded, and 166 patients with EGPA (new onset, 159; severe relapse, seven) were included. Sixty-two patients were myeloperoxidase (MPO)-ANCA positive and 104 patients were negative. No differences in age or sex were observed between the two groups. The MPO-ANCA-positive group had significantly more frequent mucous membrane and eye involvement, more frequent renal involvement, higher total Birmingham Vasculitis Activity Score, higher neutrophil counts, and higher C-reactive protein levels at baseline. Although rituximab was administered more frequently in the MPO-ANCA-positive group, no other differences in treatment were found. Both groups had comparable estimated glomerular filtration rates and prednisolone doses at weeks 24 and 48. The incidence rates of severe relapse, minor relapse, and serious infectious diseases were comparable. Cox regression analysis revealed that MPO-ANCA positivity was not a significant factor in serious infectious diseases and relapse.CONCLUSION:Patients with MPO-ANCA-positive EGPA demonstrated different baseline clinical characteristics from MPO-ANCA-negative patients. However, subsequent relapses and serious infectious diseases were comparable.
DOI	10.1080/03009742.2025.2572885
PMID	41186337