イハラ　トシコ   Toshiko Ito-Ihara   猪原　登志子    所属   川崎医科大学  医学部 応用医学　先端医療開発学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differences in phenotypes, treatments, and outcomes of ANCA-associated vasculitis across Europe, Japan and the USA in 2020.
掲載誌名	正式名：Rheumatology (Oxford, England) 略　 称：Rheumatology (Oxford) ISSNコード：14620332/14620324
掲載区分	国外
巻・号・頁	64(6),pp.3691-3700
著者・共著者	Satoshi Omura, Takashi Kida, Andreas Kronbichler, Duvuru Geetha, Hisashi Noma, Takahiro Seno, Toshiko Ito-Ihara, Nobuyuki Yajima, Takashi Kawaguchi, Naoto Tamura, Yutaka Kawahito
発行年月	2025/06
概要	OBJECTIVES:To clarify the differences in clinical phenotypes, therapeutic patterns, and outcomes of patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) across geographic regions using a multinational cohort.METHODS:Data were collected from patients with newly diagnosed or relapsing GPA or MPA in Europe, Japan and the USA from January to July 2020. The composite outcome of kidney failure and/or death within 52 weeks after treatment was evaluated, and the hazard ratios across the regions were estimated using the Cox proportional hazard model. Heterogeneities of the effects were investigated via thorough subgroup analyses.RESULTS:Among the 254 eligible patients (Europe, 137; Japan, 73; USA, 44), those in Japan were older and had higher proportions of MPO-ANCA positivity and lung involvement compared with Europe and the USA. The estimated glomerular filtration rate at diagnosis varied across regions, with the highest dialysis requirement in the USA. Cyclophosphamide and rituximab use were, respectively, 57% and 63% in Europe, 29% and 40% in Japan, and 34% and 86% in the USA. Within 52 weeks, 8%, 10% and 18% developed kidney failure, while 9%, 7% and 7% died in Europe, Japan, and the USA, respectively; and the composite outcome occurred in 15%, 14% and 23% of patients. The hazard ratios for kidney failure and/or death were comparable across regions; however, they varied among certain subgroups.CONCLUSIONS:Although the kidney failure-free survival was comparable across continents, regional differences existed in clinical phenotypes and therapeutic patterns.
DOI	10.1093/rheumatology/keae661
PMID	39786896