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イハラ トシコ
Toshiko Ito-Ihara
猪原 登志子 所属 川崎医科大学 医学部 応用医学 先端医療開発学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Novel image-guided marker aimed at organ-preserving therapies for prostate cancer. |
| 掲載誌名 | 正式名：International journal of urology : official journal of the Japanese Urological Association 略 称：Int J Urol ISSNコード：14422042/09198172 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 31(5),pp.500-506 |
| 著者・共著者 | Koji Okihara, Takashi Ueda, Atsuko Fujihara, Takumi Shiraishi, Hiroshi Iwasaki, Takeshi Nomoto, Koji Masui, Toshiko Ito-Ihara, Eri Hara, Ryusuke Nakai, Tsuyoshi Shiina, Osamu Ukimura |
| 発行年月 | 2024/05 |
| 概要 | OBJECTIVE:We developed fiducial imaging-guidance markers for the prostate with less imaging artifacts than currently commercially available markers. The aim of this study was to evaluate the imaging artifacts and potential usefulness and safety of these novel fiducial imaging markers in preclinical experiments.METHODS:We selected specific metal materials and a shape that can minimize artifacts in line with a license we obtained for a metal with a gold-platinum (Au-Pt) alloy composition that maximized artifact-free MRI images. Both phantom and canine prostate tests were conducted in order to evaluate the imaging artifacts for three imaging modalities, MRI, CT and ultrasound, and the risk of migration of the markers from the site of insertion to elsewhere, as well as crushing.RESULTS:The newly developed Au-Pt material had less imaging artifacts in the MRI, CT and ultrasound imaging modalities in comparison with current commercially available fiducial markers made from gold materials only. The Au-Pt markers had sufficient strength and durability and were considered to be potentially clinically useful and safe markers.CONCLUSION:The developed Au-Pt markers could be potential tools for accurate lesion-targeted, organ-preserving therapies such as lesion-targeted focal therapy and active surveillance in addition to conventional radiation therapies. |
| DOI | 10.1111/iju.15389 |
| PMID | 38193342 |