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ナカニシ カズオ
Kazuo Nakanishi
中西 一夫 所属 川崎医療福祉大学 リハビリテーション学部 理学療法学科 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Changes in performance status and predictive factors for poor improvement following surgery for spinal metastasis: a nationwide multicenter prospective cohort study. |
| 掲載誌名 | 正式名：The spine journal : official journal of the North American Spine Society 略 称：Spine J ISSNコード：18781632/15299430 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 26(2),pp.386-399 |
| 著者・共著者 | Akinobu Suzuki, Koji Tamai, Shinji Takahashi, Masayoshi Iwamae, Hiroshi Taniwaki, Yuki Shiratani, Takaki Shimizu, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Yohei Takahashi, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Hideaki Nakajima, Shuji Watanabe, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Haruki Funao, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Koji Uotani, Hiroaki Manabe, Shinji Tanishima, Ko Hashimoto, Chizuo Iwai, Daisuke Yamabe, Akihiko Hiyama, Shoji Seki, Yuta Goto, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Satoshi Kato, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya, |
| 発行年月 | 2026/02 |
| 概要 | BACKGROUND CONTEXT:Spinal metastasis affects the activities of daily living (ADL) of patients, and spinal surgery is aimed at improving or maintaining ADL. The Eastern Cooperative Oncology Group Performance status (ECOG-PS) is a measure of ADL, and its change after surgery can influence decisions regarding cancer treatment options. However, few detailed, large-scale studies have examined changes in ECOG-PS after surgery for spinal metastases.PURPOSE:(1) To investigate the effects of spinal surgery for metastatic spinal tumors on ECOG-PS, and (2) To identify the risk factors for poor postoperative improvement.STUDY DESIGN:Prospective multicenter cohort study.PATIENT SAMPLE:A total of 404 symptomatic patients who underwent surgical treatment for metastatic spinal tumors.OUTCOME MEASURES:ECOG-PS was designated as the primary outcome and Barthel Index (BI) as the secondary outcome. Both were assessed preoperatively and at 1 and 6 months postsurgery.METHODS:Changes in ECOG-PS and BI were analyzed using the Friedman test or a general mixed-effect model. Poor outcomes were defined as a ECOG-PS score of 3, 4, or death. Preoperative factors associated with poor outcomes were analyzed using multivariate logistic regression analyses with complete or multiple imputed datasets.RESULTS:Preoperative ECOG-PS and BI scores improved at 1 and 6 months postoperatively. Patients with a ECOG-PS score of ≤2 at 1 month had significantly higher rates of receiving systemic therapy than those with a ECOG-PS score of ≥3. No use of bone-modifying agents, Frankel grade ≥C, ECOG-PS score of ≥3, or a high C-reactive protein/albumin ratio (CAR) were the preoperative factors associated with poor PS at 1 month, whereas history of systemic therapy, ECOG-PS score of ≥3, primary tumor type, anemia, and high CAR were the preoperative factors associated with poor ECOG-PS at 6 months.CONCLUSION:Spinal surgery can improve ADL in patients with spinal metastases; however, not all patients experience favorable |
| DOI | 10.1016/j.spinee.2025.10.028 |
| PMID | 41106600 |