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フククラ ヨシヒコ
Yoshihiko Fukukura
福倉 良彦 所属 川崎医科大学 医学部 臨床医学 機能・代謝画像診断学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Oscillating Gradient Diffusion-Weighted MRI for Risk Stratification of Uterine Endometrial Cancer. |
| 掲載誌名 | 正式名：Journal of magnetic resonance imaging : JMRI 略 称：J Magn Reson Imaging ISSNコード：15222586/10531807 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 60(1),pp.67-77 |
| 著者・共著者 | Fumitaka Ejima, Yoshihiko Fukukura, Kiyohisa Kamimura, Masatoyo Nakajo, Takuro Ayukawa, Fumiko Kanzaki, Shintaro Yanazume, Hiroaki Kobayashi, Ikumi Kitazono, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura |
| 発行年月 | 2024/07 |
| 概要 | BACKGROUND:Oscillating gradient diffusion-weighted imaging (DWI) enables elucidation of microstructural characteristics in cancers; however, there are limited data to evaluate its utility in patients with endometrial cancer.PURPOSE:To investigate the utility of oscillating gradient DWI for risk stratification in patients with uterine endometrial cancer compared with conventional pulsed gradient DWI.STUDY TYPE:Retrospective.SUBJECTS:Sixty-three women (mean age: 58 [range: 32-85] years) with endometrial cancer.FIELD STRENGTH/SEQUENCE:3 T MRI including DWI using oscillating gradient spin-echo (OGSE) and pulsed gradient spin-echo (PGSE) research sequences.ASSESSMENT:Mean value of the apparent diffusion coefficient (ADC) values for OGSE (ADCOGSE) and PGSE (ADCPGSE) as well as the ADC ratio (ADCOGSE/ADCPGSE) within endometrial cancer were measured using regions of interest. Prognostic factors (histological grade, deep myometrial invasion, lymphovascular invasion, International Federation of Gynecology and Obstetrics [FIGO] stage, and prognostic risk classification) were tabulated.STATISTICAL TESTS:Interobserver agreement was analyzed by calculating the intraclass correlation coefficient. The associations of ADCOGSE, ADCPGSE, and ADCOGSE/ADCPGSE with prognostic factors were examined using the Kendall rank correlation coefficient, Mann-Whitney U test, and receiver operating characteristic (ROC) curve. A P value of <0.05 was statistically significant.RESULTS:Compared with ADCOGSE and ADCPGSE, ADCOGSE/ADCPGSE was significantly and strongly correlated with histological grade (observer 1, τ = 0.563; observer 2, τ = 0.456), FIGO stage (observer 1, τ = 0.354; observer 2, τ = 0.324), and prognostic risk classification (observer 1, τ = 0.456; observer 2, τ = 0.385). The area under the ROC curves of ADCOGSE/ADCPGSE for histological grade (observer 1, 0.92, 95% confidence intervals [CIs]: 0.83-0.98; observer 2, 0.84, 95% CI: 0.73-0.92) and prognostic risk (observer 1, 0.80, 95% CI: 0 |
| DOI | 10.1002/jmri.29106 |
| PMID | 37886909 |