スギヤマ　ヒトシ   杉山　斉    所属   川崎医療短期大学  教育部 医療介護福祉学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	SUrvey of renal Biopsy registry database and Anticancer dRUg therapy in Japan (SUBARU-J study).
掲載誌名	正式名：Clinical Kidney Journal 略　 称：Clin Kidney J
掲載区分	国外
巻・号・頁	17(12)
国際共著	国際共著
著者・共著者	Kuwabara T, Miyasato Y, Kanki T, Mizumoto T, Matsubara T, Sawa N, Sugiyama H, Maruyama S, Sato H, Tsukamoto T, Murata T, Miyazaki M, Imasawa T, Mukoyama M, Murakami N, Jhaveri KD, Yanagita M; JSN Onconephrology working group.
発行年月	2024/11/28
概要	We aimed to investigate the real-world clinical outcomes of anticancer drug therapy-associated renal complications in Japan using the national kidney biopsy database, Japan Renal Biopsy Registry (J-RBR). The most common primary sites of malignancies were the lung (33.3%), followed by gastrointestinal (16.3%) and gynaecological (11.1%) cancers. Tubulointerstitial nephritis (TIN; 47.4%) and thrombotic microangiopathy (TMA; 35.6%) were the most frequent diagnoses. All immunoglobulin A nephropathy, minimal change disease and crescentic glomerulonephritis (CrGN) cases were immune checkpoint inhibitor related. All CrGN cases were anti-neutrophil cytoplasmic antibody negative. Antibiotics were most frequently used concomitantly with anticancer drugs in TMA cases among subgroups (TMA versus others: 62.5 versus 27.5%; P < .001). Among TMA cases, the serum lactate dehydrogenase level tended to be higher in cytotoxic agent-associated TMA (CTx-TMA) than in other TMAs, but was not significant between groups (415.5 versus 219.0 U/l; P = .06). Overall survival was worse in CTx-TMA than in other TMAs (P = .007). The Cox model demonstrated proton pump inhibitor (PPI) use (hazard ratio 2.49, P = .001) as a significant prognostic factor, as well as the presence of metastasis and serum albumin level. Conclusions: Our registry analysis highlighted various presentations of biopsy-proven kidney complications associated with anticancer drug therapy. Clinicians should be aware of worse outcomes associated with CTx-TMA and the prognostic role of PPI use.
DOI	10.1093/ckj/sfae327
PMID	39664993