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イトウ タツオ
Tatsuo Ito
伊藤 達男 所属 川崎医科大学 医学部 応用医学 衛生学 職種 教授 |
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| 論文種別 | 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Comparing immunopathogenesis of non-human immunodeficiency virus immune reconstitution inflammatory syndrome and immune-related adverse events: A prospective multicenter cohort study. |
| 掲載誌名 | 正式名：The Journal of dermatology 略 称：J Dermatol ISSNコード：13468138/03852407 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 52(6),pp.1015-1030 |
| 著者・共著者 | Hirohiko Sueki, Seiko Sugiyama, Yumi Aoyama, Takenobu Yamamoto, Hideaki Watanabe, Naoko Inomata, Yutaro Kubota, Atsushi Horiike, Takuya Tsunoda, Toru Tanaka, Yuko Watanabe, Yukie Yamaguchi, Yoshiko Mizukawa, Yukihiko Kato, Natsumi Hama, Riichiro Abe, Kazuteru Noguchi, Kiyoshi Matsui, Hiroyuki Niihara, Takemi Otsuki, Yurika Shimizu, Tatsuo Ito, Eisuke Inoue, Kaoru Kubota |
| 発行年月 | 2025/06 |
| 概要 | The concept of immune reconstitution inflammatory syndrome (IRIS) has recently been applied to patients with non-HIV infection with immune fluctuations. However, quantitative criteria to diagnose non-HIV IRIS have not been established. Similarly, immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) are also caused by immune fluctuations. No study has directly compared the immunological indicators of non-HIV IRIS and irAEs. Thus, we investigated whether irAEs can be included in non-HIV IRIS. We aimed to search for diagnostic biomarkers for non-HIV IRIS and to compare the immunopathogenesis of non-HIV IRIS and irAEs based on immunological indicators. We selected drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) and dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid (DPP4i-BP) as underlying diseases of non-HIV IRIS. Blood cell counts, cytokines or chemokines, and herpesvirus-derived DNA in saliva were quantified and compared between IRIS/irAE-positive and -negative as well as non-HIV IRIS and irAEs groups. The DPP4i-BP group had a shorter incubation time to IRIS onset than the DIHS/DRESS group; the irAE group had a longer incubation time than the DIHS/DRESS group. A higher neutrophil-to-lymphocyte ratio and serum interferon gamma inducible protein 10 levels could be potential biomarkers of IRIS and irAEs onset; however, no useful cut-off values for diagnosis were indicated. Meanwhile, the transition of regulatory T cells (Tregs) from the baseline to the onset of IRIS or irAEs differed between IRIS in DIHS/DRESS and irAEs. Only the DIHS/DRESS group showed an increase of Epstein-Bar virus (EBV) (p < 0.0001) and human herpesvirus 6 (p < 0.05) positivity in saliva at the onset of IRIS compared to that at baseline. Although non-HIV IRIS and irAEs have a small number of common immunological indicators, the dynamics of Tregs, cytokines, or chemokines and positivity of herpesvir |
| DOI | 10.1111/1346-8138.17706 |
| PMID | 40156255 |