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イシハマ タカノリ
Takanori Ishihama
石濱 嵩統 所属 川崎医科大学 医学部 臨床医学 歯科総合口腔医療学 職種 臨床助教８年 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognostic impact of the prognostic nutritional index in cases of resected oral squamous cell carcinoma: a retrospective study. |
| 掲載誌名 | 正式名：BMC oral health 略 称：BMC Oral Health ISSNコード：14726831/14726831 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 21(1),pp.40 |
| 著者・共著者 | Atsushi Abe, Hiroki Hayashi, Takanori Ishihama, Hiroshi Furuta |
| 発行年月 | 2021/01 |
| 概要 | BACKGROUND:The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery.METHODS:From 2008 to 2019, 102 patients (73 males, 29 females; age, 65.6 ± 9.8 years) who visited our hospital and underwent surgical therapy were included in this study. The endpoint was the total survival period, and the evaluation markers included the lymphocyte count and albumin level in peripheral blood obtained 4 weeks preoperatively, age, sex, alcohol consumption, smoking history, site of the tumor, pathological stage, and surgery status. The PNI was calculated using serum albumin levels and the peripheral blood lymphocyte count. The relationship between the PNI and patient characteristics were analyzed using Fisher's exact test. The Kaplan-Meier method was used to evaluate the survival rate. The survival periods were compared using the log-rank method. We evaluated the prognostic factors for overall survival (OS) and disease-free survival (DFS) in a logistic regression model.RESULTS:The tumor sites included the maxilla (n = 12), buccal mucosa (n = 11), mandible (n = 17), floor of the mouth (n = 9), and tongue (n = 53). The number of patients with stage I, II, III, and IV oral cancers was 28 (27.5%), 34 (27.5%), 26 (33.3%), and 14 (13.7%), respectively. During the observation period, 21 patients died of head and neck cancer. The optimal cut-off PNI value was 42.9, according to the receiver operating characteristic analysis. The proportion of patients with a short OS was lower in those with PNI higher than 42.9, and the 5-year OS in patients with PNI higher and lower than the cut-off value was 62.3% and 86.0%, respectively (P = 0.0105).CONCLUSIONS:The OS of patients with PNI < 42.9 was lower than that of patients with PNI ≥ 42.9. The PNI, which is a preoperat |
| DOI | 10.1186/s12903-021-01394-6 |
| PMID | 33482792 |