イマタキ　オサム   Osamu Imataki   今滝　修    所属   川崎医科大学  医学部 臨床医学　検査診断学（病態解析）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans.
掲載誌名	正式名：Journal of functional biomaterials 略　 称：J Funct Biomater ISSNコード：20794983/20794983
掲載区分	国外
巻・号・頁	15(12)
著者・共著者	Yasuo Komura, Shintarou Kimura, Yumi Hirasawa, Tomoko Katagiri, Ayana Takaura, Fumika Yoshida, Saki Fukuro, Hiromi Muranishi, Osamu Imataki, Koichiro Homma
発行年月	2024/12
概要	Photodynamic therapy (PDT) is a minimally invasive treatment that elicits tumor apoptosis using laser light exclusively applied to the tumor site. IR-783, a heptamethine cyanine (HMC) dye, impedes the proliferation of breast cancer cells, even without light. Although studies have investigated the efficacy of IR-783 in cell and animal studies, its efficacy in clinical settings remains unknown. Therefore, we aimed to determine the efficacy of PDT using IR-783 liposomes. An HMC dye, excited by long-wavelength infrared light and with high tissue permeability, was used for PDT after liposomization to enhance tumor tissue accumulation. PDT was performed using IR-783 in two patients with either tongue or breast cancer, one each. IR-783 liposomes inhibited cell proliferation in tongue cancer cells even when not excited by light. Tumor size was markedly reduced in both cases, with no significant adverse events. Furthermore, the patient with tongue cancer exhibited improved respiratory, swallowing, and speech functions, which were attributed not only to the shrinkage of the tumor but also to the improvement in airway narrowing. In conclusion, PDT using IR-783 liposomes effectively reduces tumor size in tongue and breast cancers.
DOI	10.3390/jfb15120363
PMID	39728163