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ババ ノブヤス
馬場 伸育 所属 川崎医科大学 医学部 基礎医学 免疫学 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Interplay between CD45RA+ regulatory T cells and TNF-alpha in the regulation of human Th17 differentiation. |
| 掲載誌名 | 正式名：International immunology 略 称：Int Immunol ISSNコード：14602377/09538178 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 22(4),pp.237-44 |
| 著者・共著者 | Nobuyasu Baba, Manuel Rubio, Marika Sarfati |
| 発行年月 | 2010/04 |
| 概要 | The balance between effector CD4(+) T cells secreting IL-17 (T(h)17) and regulatory T cells (Treg) plays an important role in autoimmune disorders that include rheumatoid arthritis (RA) and Crohn's disease. Tumor necrosis factor (TNF)-alpha is a key pro-inflammatory cytokine that contributes to disease pathogenesis. We investigated the interplay between CD45RA(+) Treg and TNF-alpha in the regulation of human T(h)17 differentiation. We found that CD45RA(+) Treg promoted while TNF-alpha inhibited naive CD4(+) T-cell differentiation into IL-17 and CCL20 co-expressing T(h)17 cells without influencing their IL-22 release. Unexpectedly, CD45RA(+) Treg depletion abrogated TNF-alpha suppressive function. Finally, dendritic cell-derived TNF-alpha suppressed the development of IL-17(+)CCL20(+) expressing T(h)17 cells. In conclusion, CD45RA(+) Treg positively governs human T(h)17 development, which is impaired by TNF-alpha. We propose that TNF-alpha may represent a negative feedback mechanism to control IL-17/CCL20- but not IL-22-associated autoimmune pathologies. |
| DOI | 10.1093/intimm/dxp130 |
| PMID | 20181653 |