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イツミ モモエ
逸見 百江 所属 川崎医科大学 医学部 一般教養 自然科学 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Pathogenic effects of Streptococcus oralis intestinal colonization on bladder health in mice. |
| 掲載誌名 | 正式名：Current research in microbial sciences 略 称：Curr Res Microb Sci ISSNコード：26665174/26665174 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 8,pp.100375 |
| 著者・共著者 | Natsuno Nakamura, Kota Iioka, Hirobumi Morisaki, Nobuo Okahashi, Mie Kurosawa, Haruka Fukamachi, Shohei Matsui, Takahiro Funatsu, Hirotaka Kuwata, Momoe Itsumi |
| 発行年月 | 2025 |
| 概要 | Streptococcus oralis, a commensal oral Streptococcus, is known as an early colonizer of the tooth surface and causes opportunistic infections, such as bacterial endocarditis. However, its pathogenicity remains unclear. This study aimed to investigate the pathogenicity of S. oralis in vivo using a mouse model. To establish S. oralis-colonized mice, germ-free mice were orally infected with S. oralis. After colonization was confirmed, these infected mice were bred, and their offspring were used as S. oralis-colonized mice. S. oralis was detected only in the intestine of these mice, which exhibited soft stools but no significant inflammation in the examined tissues. Interestingly, S. oralis-colonized mice showed higher urination frequency. Bladder tissue analysis in S. oralis-colonized mice revealed atrophy, edema, fibrosis, and epithelial denudation. RNA sequencing analysis of the bladder in S. oralis-colonized mice indicated higher expression of genes related to chronic inflammation and extracellular matrix organization, and lower expression of genes related to anti-oxidative stress. In this study, we revealed that the commensal bacterium S. oralis induces chronic inflammation and fibrosis in the bladder of mice by intestinal colonization. Hence, our findings indicate that S. oralis has the potential to affect distal tissue beyond the oral cavity, potentially possessing a pathogenic factor involved in non-bacterial cystitis. This study highlights the potential impact of S. oralis on the urinary system of mice. |
| DOI | 10.1016/j.crmicr.2025.100375 |
| PMID | 40207138 |