イツミ　モモエ   逸見　百江    所属   川崎医科大学  医学部 一般教養　自然科学    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Largen: a molecular regulator of mammalian cell size control.
掲載誌名	正式名：Molecular cell 略　 称：Mol Cell ISSNコード：10974164/10972765
掲載区分	国外
巻・号・頁	53(6),pp.904-15
著者・共著者	Kazuo Yamamoto, Valentina Gandin, Masato Sasaki, Susan McCracken, Wanda Li, Jennifer Liepa Silvester, Andrew J Elia, Feng Wang, Yosuke Wakutani, Roumiana Alexandrova, Yathor D Oo, Peter J Mullen, Satoshi Inoue, Momoe Itsumi, Valentina Lapin, Jillian Haight, Andrew Wakeham, Arda Shahinian, Mitsuhiko Ikura, Ivan Topisirovic, Nahum Sonenberg, Tak W Mak
発行年月	2014/03
概要	Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human cells. In vitro evidence indicated that Largen preferentially stimulates the translation of specific subsets of mRNAs, including those encoding proteins affecting mitochondrial functions. The involvement of Largen in mitochondrial respiration was consistent with the increased mitochondrial mass and greater ATP production in Largen-overexpressing cells. Furthermore, Largen overexpression led to increased cell size in vivo, as revealed by analyses of conditional Largen transgenic mice. Our results establish Largen as an important link between mRNA translation, mitochondrial functions, and the control of mammalian cell size.
DOI	10.1016/j.molcel.2014.02.028
PMID	24656129