|
マツトモ ノリカズ
松友 紀和 所属 川崎医療福祉大学 医療技術学部 診療放射線技術学科 職種 特任准教授 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Pilot study of a novel resection extent determination method using bone single-photon emission computed tomography-standardized uptake value in medication-related osteonecrosis of the jaw. |
| 掲載誌名 | 正式名：Dento maxillo facial radiology 略 称：Dentomaxillofac Radiol ISSNコード：1476542X/0250832X |
| 掲載区分 | 国外 |
| 著者・共著者 | Naoya Hayashi, Norikazu Matsutomo, Ryotaro Tokorodani, Mitsuha Fukami, Miki Nishimori, Kie Nakatani, Yukio Yoshioka, Yoshihiro Hayashi, Ichiro Murakami, Takuji Yamagami, Tetsuya Yamamoto, Tomoaki Yamamoto |
| 発行年月 | 2025/04 |
| 概要 | OBJECTIVE:Surgery is the standard treatment for medication-related osteonecrosis of the jaw (MRONJ). However, there are few reports on the appropriate extent of the bone resection. This pilot study explores the feasibility of a new method for estimating the extent of resection using bone single-photon emission computed tomography (SPECT)-standardized uptake value (SUV).METHODS:We retrospectively analyzed 8 MRONJ patients who underwent curettage (n = 2), curettage with removal of the separated sequestrum (n = 2), or marginal resection (n = 4) as part of extensive surgery. The resected regions were compared with the regions estimated using SPECT-SUV. The agreement between the SPECT cold region and the resected region was evaluated using the Dice coefficient (defined as the ratio of 2 × overlap volume to resected volume plus SPECT cold region volume), overlap ratio, and volume ratio. The inclusion of CT findings (osteolytic, gap- and irregular-type periosteal reactions, and mixed-type osteosclerosis) in the estimated region was also evaluated. Additionally, histopathological findings from 3 marginal resection cases were used to validate the estimated region.RESULTS:In all cases, the resected region included the cold regions observed on bone SPECT, with radiotracer accumulation confirmed around the resected region. CT-osteolytic regions were included within the estimated region. The Dice coefficient was 0.53 ± 0.10, the overlap ratio was 86.7 ± 7.2%, and the volume ratio was 235.0 ± 74.7%. Histopathological analysis revealed significant osteocyte necrosis in cold regions, whereas areas with an SUV of 9 displayed normal osteocytes, newly formed bone, and mild inflammatory cell infiltration.CONCLUSION:This study suggests that the setting of the SPECT-cold region using bone SPECT-SUV may allow for the estimation of the extent of resection in early-to-intermediate-stage MRONJ. |
| DOI | 10.1093/dmfr/twaf032 |
| PMID | 40233239 |