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マツトモ ノリカズ
松友 紀和 所属 川崎医療福祉大学 医療技術学部 診療放射線技術学科 職種 特任准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Validation of the CT iterative reconstruction technique for low-dose CT attenuation correction for improving the quality of PET images in an obesity-simulating body phantom and clinical study. |
| 掲載誌名 | 正式名：Nuclear medicine communications 略 称：Nucl Med Commun ISSNコード：14735628/01433636 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 36(8),pp.839-47 |
| 著者・共著者 | Norikazu Matsutomo, Akio Nagaki, Masayuki Sasaki |
| 発行年月 | 2015/08 |
| 概要 | OBJECTIVE:The aim of this study was to validate the efficacy of computed tomography (CT) iterative reconstruction (CT-IR) for low-dose CT attenuation correction in terms of the estimation of attenuation coefficient and quality of PET images.MATERIALS AND METHODS:We used normal and obesity-simulating body phantoms. PET images were reconstructed using two attenuation correction maps obtained using filtered back projection (CT-FBP) and CT-IR. The CT numbers, attenuation coefficients, contrast-to-noise ratio (CNR10 mm), and coefficient of variation were evaluated. Fifty-two consecutive patients who underwent F-FDG PET/CT with low-dose CT scans were selected for the clinical study. Clinical PET images were reconstructed using CT-FBP and CT-IR, and the effects of CT-IR were examined according to the maximum standardized uptake value (SUVmax), contrast-to-noise ratio in the tumor (CNRtumor), and signal-to-noise ratio in the liver (SNRliver).RESULTS:The CT number on the CT-IR was significantly lower than that of CT-FBP in the obesity-simulating body phantom. The decrease in attenuation coefficients obtained using CT-IR was smaller than that obtained using CT-FBP. The CNR10 mm and coefficient of variation obtained using CT-IR were superior to those obtained using CT-FBP. The SUVmax was not significantly different between the CT-FBP and CT-IR. Although the difference in the SNRliver between the CT-FBP and CT-IR was not significant, the CNRtumor of the CT-IR was significantly higher than that obtained using CT-FBP in obese patients.CONCLUSION:We demonstrated that CT-IR improved the estimation of the attenuation coefficient and provided significant improvement in the CNR of the clinical PET images. |
| DOI | 10.1097/MNM.0000000000000326 |
| PMID | 25920050 |