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スズキ ケイタ
Keita Suzuki
鈴木 啓太 所属 川崎医療福祉大学 リハビリテーション学部 理学療法学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Differential associations between selenoprotein P and distal sensorimotor polyneuropathy in people with and without diabetes: KORA F4/FF4 study. |
| 掲載誌名 | 正式名：Free radical biology & medicine 略 称：Free Radic Biol Med ISSNコード：18734596/08915849 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 223,pp.87-95 |
| 国際共著 | 国際共著 |
| 著者・共著者 | Christian Herder, Yoshiro Saito, Maria C Spagnuolo, Haifa Maalmi, Misaki Shimizu, Gidon J Bönhof, Keita Suzuki, Wolfgang Rathmann, Annette Peters, Michael Roden, Dan Ziegler, Barbara Thorand, Toshinari Takamura |
| 発行年月 | 2024/10 |
| 概要 | BACKGROUND:Oxidative stress is a risk factor for distal sensorimotor polyneuropathy (DSPN). Selenoprotein P is a protein with antioxidant properties but has not been investigated in the context of DSPN. This study aimed to assess the associations between selenoprotein P and DSPN in people without and with type 2 diabetes (T2D).METHODS:Cross-sectional and prospective analyses were based on 1053 (including 217 with T2D) and 513 participants (including 79 with T2D), respectively, aged 61-82 years from the population-based KORA F4 survey. DSPN at baseline (KORA F4) and in the follow-up survey KORA FF4 was defined based on the Michigan Neuropathy Screening Instrument. Serum levels of full-length selenoprotein P were quantified by ELISA. Associations between selenoprotein P and prevalent or incident DSPN were estimated using logistic regression analysis adjusting for multiple confounders.RESULTS:Selenoprotein P levels were not associated with prevalent DSPN in the total sample. However, there was a significant interaction by diabetes status. Higher levels of selenoprotein P were associated with lower odds of prevalent DSPN in individuals without T2D (fully adjusted model: OR 0.825 [95 % CI 0.682, 0.998], p = 0.0476), but not in those with T2D (OR [95 % CI] 1.098 [0.829, 1.454], p = 0.5132; pinteraction = 0.0488). Selenoprotein P levels were not associated with incident DSPN over a follow-up of 6.5 years.CONCLUSION:In individuals without T2D from the older general population, lower selenoprotein P levels were associated with a higher prevalence of DSPN. Whether the antioxidant properties of selenoprotein P are responsible for the observed associations remains to be elucidated in future research. |
| DOI | 10.1016/j.freeradbiomed.2024.07.028 |
| PMID | 39059514 |