ミタニ　シゲル   Shigeru Mitani   三谷　茂    所属   川崎医科大学  医学部 臨床医学　脊椎・関節整形外科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Efficacy of S-Flurbiprofen Plaster for Analgesia Following Total Hip Arthroplasty.
掲載誌名	正式名：Cureus 略　 称：Cureus ISSNコード：21688184/21688184
掲載区分	国外
巻・号・頁	16(8),pp.e66805
著者・共著者	Yoshiaki Miyake, Shigeru Mitani, Yoshifumi Namba, Norifumi Umehara, Toyohiro Kawamoto, Shuro Furuichi
担当区分	2nd著者
発行年月	2024/08
概要	PURPOSE:S-flurbiprofen (SFP) plaster, a non-steroidal anti-inflammatory drug preparation that penetrates effectively into deep tissue, is currently used as a conservative treatment for osteoarthritis. We investigated the analgesic and adverse effects of SFP plaster after total hip arthroplasty (THA).METHODS:A retrospective comparative study identified 100 patients who underwent primary THA in our department. Group A consisted of 50 patients who received the selective cyclooxygenase-2 inhibitor celecoxib for 14 days after surgery, while Group B consisted of 50 patients who received SFP plaster for 14 days after surgery. We noted the numerical rating pain intensity scale (NRS) score, body temperature, and adverse effects of the analgesics.RESULTS:Groups A and B showed no significant difference in NRS scores (p > 0.05). The body temperature was significantly higher in Group B than in Group A on days one, two, three, and five (p < 0.01). In Group A, two patients (4%) showed drug-induced renal dysfunction, and one patient (2%) showed gastrointestinal disturbance. Patients in Group B showed no systemic or local adverse effects.CONCLUSIONS:The application of SFP plaster after THA provided an analgesic effect similar to that obtained with oral celecoxib without causing obvious side effects. Applying an SFP plaster may be an effective solution for postoperative analgesia.
DOI	10.7759/cureus.66805
PMID	39280551