ミタニ　シゲル   Shigeru Mitani   三谷　茂    所属   川崎医科大学  医学部 臨床医学　脊椎・関節整形外科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Predicting Skeletal-related Events Using SINS.
掲載誌名	正式名：Spine 略　 称：Spine (Phila Pa 1976) ISSNコード：15281159/03622436
掲載区分	国外
巻・号・頁	49(22),pp.E367-E371
著者・共著者	Kazuo Nakanishi, Yasukazu Hijikata, Kazuya Uchino, Yoshihisa Sugimoto, Hideaki Iba, Seiya Watanabe, Shigeru Mitani
担当区分	最終著者
発行年月	2024/11/15
概要	STUDY DESIGN:Predictive study utilized retrospectively collected data.OBJECTIVE:The primary objective was to evaluate the predictive association between the Spine Instability Neoplastic Score (SINS) and Skeletal-related events (SREs). Secondary objectives included examining characteristics of cases with SINS ≤ 6 among those who developed SRE and evaluating the impact of additional predictors on prediction accuracy.SUMMARY OF BACKGROUND DATA:Advances in cancer treatment have prolonged the lives of cancer patients, emphasizing the importance of maintaining quality of life. SREs from metastatic spinal tumors significantly impact the quality of life. However, currently, there is no scientifically established method to predict the occurrence of SRE. SINS, developed by the Spine Oncology Study Group, assesses spinal instability using six categories. Therefore, the predictive performance of SINS for SRE occurrence is of considerable interest to clinicians.METHODS:This predictive study utilized retrospectively collected data from a single-center registry comprising over 1000 patients with metastatic spinal tumors. SINS and clinical data were collected. Logistic regression was used to create a prediction equation for SRE using SINS. Additional analyses explored factors associated with SRE in patients with SINS ≤ 6.RESULTS:The study included 1041 patients with metastatic spinal tumors. SRE occurred in 121 cases (12%). The prediction model for SRE using SINS demonstrated an area under the curve (AUC) of 0.832. Characteristics associated with SRE included lower female prevalence, surgeries to primary sites, bone metastases to nonspinal sites, and metastases to other organs. A post hoc analysis incorporating additional predictors improved the AUC to 0.865.CONCLUSIONS:The SINS demonstrated reasonable predictive performance for SRE within one month of the initial visit. Incorporating additional factors improved prediction accuracy. The study emphasizes the need for a comprehensive
DOI	10.1097/BRS.0000000000004983
PMID	38475677