ミウラ　マズミ   Mazumi Miura   三浦　真澄    所属   川崎医科大学  医学部 臨床医学　小児科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression.
掲載誌名	正式名：Yonago acta medica
掲載区分	国内
巻・号・頁	64(1),pp.57-66
著者・共著者	Satoshi Narai,Yuki Kawashima-Sonoyama,Masanobu Fujimoto,Mazumi Miura,Kaori Adachi,Eiji Nanba,Noriyuki Namba
発行年月	2021/02
概要	Background: Insulin and insulin-like growth factor (IGF) signaling plays an important role in prenatal and postnatal growth and glucose metabolism. Both small-for-gestational age (SGA) and preterm infants have abnormal growth and glucose metabolism. However, the underlying mechanism remains unknown. Recently, we showed that term SGA infants have abnormal insulin/IGF signaling in cord blood. In this study, we examined whether preterm infants show similar aberrations in cord blood insulin/IGF signaling. Methods: A total of 41 preterm cord blood samples were collected. Blood glucose, insulin, IGF-1, and C-peptide concentrations were measured, and mRNA expression of IGF1R, INSR, IRS1, IRS2, and SLC2A4 (i.e., GLUT4) was analyzed by quantitative reverse-transcription PCR. Results: This study included 34 appropriate-for-gestational age (AGA) and 7 SGA preterm neonates. No hyperinsulinemia or any differences in IGF1R or INSR mRNA expression were detected between the two groups. However, GLUT4 mRNA levels were increased in preterm SGA. Moreover, the expression level in hypoglycemic preterm SGA was significantly higher than that in hypoglycemic preterm AGA. IRS2 mRNA expression did not show a statistically significant difference between preterm SGA and AGA neonates. Conclusion: SGA preterm birth does not induce hyperinsulinemia; however, it modifies insulin/IGF signaling components such as GLUT4 in umbilical cord blood. Our study suggests that prematurity or adaptation to malnutrition alters the insulin/IGF signaling pathway.
DOI	10.33160/yam.2021.02.009
PMID	33642904