ヤマウチ　アキラ   Akira Yamauchi   山内　明    所属   川崎医科大学  医学部 基礎医学　生化学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Anti-fatigue activity of methyl dihydrojasmonate and linalool in a rat model evaluated by a novel index for neuro-immune and oxidative stress interactions
掲載誌名	正式名：Scientific Reports 略　 称：Sci Rep ISSNコード：20452322
掲載区分	国外
出版社	Springer Nature Limited
巻・号・頁	14
総ページ数	10
著者・共著者	Yasumitsu Nishimura, Kenta Nomiyama, Shuichiro Okamoto, Mika Igarashi, Yukino Sato, Hikaru Okamoto, Ayasa Kamezaki, Masumi Itadani, Futoshi Kuribayashi & Akira Yamauchi
担当区分	最終著者,責任著者
発行年月	2024/05/09
概要	Avoiding fatigue is a long-standing challenge in both healthy and diseased individuals. Establishing objective standard markers of fatigue is essential to evaluate conditions in spatiotemporally different locations and individuals and identify agents to fight against fatigue. Herein, we introduced a novel method for evaluating fatigue using nervous system markers (including dopamine, adrenaline, and noradrenaline), various cytokine levels (such as interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-10, IL-2, IL-5 and IL-17A), and oxidative stress markers (such as diacron-reactive oxygen metabolites [d-ROMs] and biological antioxidant potential [BAP]) in a rat fatigue model. Using this method, the anti-fatigue effects of methyl dihydrojasmonate (MDJ) and linalool, the fragrance/flavor compounds used in various products, were assessed. Our method evaluated the anti-fatigue effects of the aforementioned compounds based on the changes in levels of the nerves system markers, cytokines, and oxidative stress markers. MDJ exerted more potent anti-fatigue effects than linalool. In conclusion, the reported method could serve as a useful tool for fatigue studies and these compounds may act as effective therapeutic agents for abrogating fatigue symptoms.
DOI	https://doi.org/10.1038/s41598-024-60266-5
PMID	38724532