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スズキ ケイタ
Keita Suzuki
鈴木 啓太 所属 川崎医療福祉大学 リハビリテーション学部 理学療法学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men. |
| 掲載誌名 | 正式名：Journal of diabetes investigation 略 称：J Diabetes Investig ISSNコード：20401124/20401116 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 12(5),pp.869-876 |
| 著者・共著者 | Sakae Miyagi, Toshinari Takamura, Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Akinori Hara, Haruki Nakamura, Keita Suzuki, Atsushi Tajima, Takayuki Kannon, Tadashi Toyama, Yasuhiro Kambayashi, Hiroyuki Nakamura |
| 発行年月 | 2021/05 |
| 概要 | AIMS/INTRODUCTION:A low insulin secretion capacity has been implicated in the high prevalence of non-obese diabetes in East Asians. As alcohol consumption alters insulin and glucose metabolism, we tested the hypothesis that alcohol consumption contributes to impaired insulin secretion and glucose intolerance in lean/normal-weight non-diabetic Japanese men.MATERIALS AND METHODS:This cross-sectional study was undertaken among the residents of Shika town, Japan, between 2011 and 2017. A total of 402 non-diabetic men, including participants with normal fasting plasma glucose (FPG) and impaired FPG (FPG 5.6-6.9 mmol/L), and aged ≥40 years, were examined. FPG, the homeostasis model assessment of insulin secretion capacity (HOMA-B) and alcohol consumption were evaluated and compared between the body mass index (BMI) <25 and BMI ≥25 groups.RESULTS:HOMA-B levels were lower in the BMI <25 group than in the BMI ≥25 group. Alcohol consumption correlated with a low HOMA-B level regardless of BMI, and, thus, the HOMA-B levels of alcohol drinkers were significantly lower in the BMI <25 group. A multivariable logistic regression analysis showed that alcohol consumption, even light-to-moderate consumption (1-25 g/day), was associated with significantly low levels of HOMA-B and impaired FPG in the BMI <25 group. Among participants with impaired FPG, a low level of HOMA-B was observed in alcohol drinkers, but not in non-drinkers. In contrast, light-to-moderate alcohol consumption was not related to HOMA-B or FPG in the BMI ≥25-group.CONCLUSION:Alcohol consumption, even a small amount, might contribute to reductions in HOMA-B levels and impaired FPG in lean/normal-weight Japanese men. |
| DOI | 10.1111/jdi.13402 |
| PMID | 32910554 |