スズキ　ケイタ   Keita Suzuki   鈴木　啓太    所属   川崎医療福祉大学  リハビリテーション学部 理学療法学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population.
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：19326203/19326203
掲載区分	国外
巻・号・頁	16(8),pp.e0255444
著者・共著者	Youhei Yamada, Haruki Nakamura, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Yukari Shimizu, Kim Oanh Pham, Keita Suzuki, Fumihiko Suzuki, Tomoko Kasahara, Hirohito Tsuboi, Atsushi Tajima, Hiroyuki Nakamura
発行年月	2021
概要	A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.
DOI	10.1371/journal.pone.0255444
PMID	34347822