スズキ　ケイタ   Keita Suzuki   鈴木　啓太    所属   川崎医療福祉大学  リハビリテーション学部 理学療法学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Association Between Serum 25-Hydroxyvitamin D Concentrations, CDX2 Polymorphism in Promoter Region of Vitamin D Receptor Gene, and Chronic Pain in Rural Japanese Residents.
掲載誌名	正式名：Journal of pain research 略　 称：J Pain Res ISSNコード：11787090/11787090
掲載区分	国外
巻・号・頁	15,pp.1475-1485
著者・共著者	Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Oanh Kim Pham, Sakae Miyagi, Thao Thi Thu Nguyen, Haruki Nakamura, Fumihiko Suzuki, Tomoko Kasahara, Yukari Shimizu, Yohei Yamada, Yasuhiro Kambayashi, Hirohito Tsuboi, Takehiro Sato, Takayuki Kannon, Kazuyoshi Hosomichi, Atsushi Tajima, Toshinari Takamura, Hiroyuki Nakamura
担当区分	筆頭著者,責任著者
発行年月	2022/05
概要	BACKGROUND:Previous studies examined the association between chronic pain (CP) and serum 25-hydroxyvitamin D (25(OH)D) concentrations; however, the findings obtained were inconsistent. Single nucleotide polymorphisms (SNP) associated with the transcriptional activity of the vitamin D receptor (VDR) gene may influence the association of 25(OH)D levels with CP. We aimed to clarify the association between CP, serum 25(OH)D concentration, and SNPs.METHODS:In the Shika study, we performed a cross-sectional analysis of 551 participants older than 40 years who were asked whether they had been having persistent pain lasting for at least 3 months in any part of the body on a self-administered questionnaire. Serum 25(OH)D concentrations were assessed as a biomarker of the vitamin D status using a radioimmunoassay. rs731236, rs7975232, rs1544410, rs2228570, and rs11568820 were identified using peripheral blood samples, and participants were assigned to those with or without the minor allele for each SNP.RESULTS:The prevalence of CP was 37.2%. We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. Furthermore, a logistic regression analysis revealed that lower serum 25(OH)D concentrations were significantly associated with CP in the hetero/minor group, but not in the major group.CONCLUSION:These results suggest that sufficient serum 25(OH)D concentration reduces the risk of CP in individuals with the minor allele of the CDX2 polymorphism.
DOI	10.2147/JPR.S356630
PMID	35633918