トクトミ　トモハル   Tomoharu Tokutomi   徳富　智明    所属   川崎医科大学  医学部 臨床医学　小児科学    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Population-based biobank participants' preferences for receiving genetic test results.
掲載誌名	正式名：Journal of human genetics ISSNコード：1434-5161/1435-232X
掲載区分	国外
出版社	NATURE PUBLISHING GROUP
巻・号・頁	62(12),pp.1037-1048
著者・共著者	Kayono Yamamoto,Tsuyoshi Hachiya,Akimune Fukushima,Naoki Nakaya,Akira Okayama,Kozo Tanno,Fumie Aizawa,Tomoharu Tokutomi,Atsushi Hozawa,Atsushi Shimizu
発行年月	2017/12
概要	There are ongoing debates on issues relating to returning individual research results (IRRs) and incidental findings (IFs) generated by genetic research in population-based biobanks. To understand how to appropriately return genetic results from biobank studies, we surveyed preferences for returning IRRs and IFs among participants of the Tohoku Medical Megabank Project (TMM). We mailed a questionnaire to individuals enrolled in the TMM cohort study (Group 1; n=1031) and a group of Tohoku region residents (Group 2; n= 2314). The respondents were required to be over 20 years of age. Nearly 90% of Group 1 participants and over 80% of Group 2 participants expressed a preference for receiving their genetic test results. Furthermore, over 60% of both groups preferred to receive their genetic results 'from a genetic specialist.' A logistic regression analysis revealed that engaging in 'health-conscious behaviors' (such as regular physical activity, having a healthy diet, intentionally reducing alcohol intake and/ or smoking and so on) was significant, positively associated with preferring to receive their genetic test results (odds ratio=2.397 (Group 1) and 1.897 (Group 2)). Our findings provided useful information and predictors regarding the return of IRRs and IFs in a population-based biobank.
DOI	10.1038/jhg.2017.81
PMID	28794501