ウネ　ダイ   Dai Une   畝　大    所属   川崎医科大学  医学部 臨床医学　心臓血管外科学    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis.
掲載誌名	正式名：The journal of physiological sciences : JPS 略　 称：J Physiol Sci ISSNコード：18806562/18806546
掲載区分	国内
巻・号・頁	66(3),pp.249-55
著者・共著者	Shuji Shimizu, Toru Kawada, Dai Une, Masafumi Fukumitsu, Michael James Turner, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi
発行年月	2016/05
概要	Cavopulmonary assist (CPA) for failing Fontan patients remains a challenging issue in the clinical setting. To evaluate the effectiveness of a partial CPA from the inferior vena cava (IVC) to the pulmonary artery (PA), we performed a theoretical analysis using a computational model of the Fontan circulation. Cardiac chambers and vascular systems were described as the time-varying elastance model and the modified three-element Windkessel model, respectively. A rotational pump described as a non-linear function was inserted between the IVC and the PA. When pulmonary vascular resistance index varied from 2.1 to 5.9 Wood units m(2), the partial CPA maintained cardiac index as efficiently as total CPA and markedly reduced the IVC pressure compared with total CPA. However, the partial CPA increased the superior vena cava pressure substantially. The modification from total to partial CPA is potentially an effective alternative in failing Fontan patients suffering from high IVC pressure.
DOI	10.1007/s12576-015-0422-3
PMID	26546008