ヤマニシ　ハルヨ   Haruyo Yamanishi   山西　治代    所属   川崎医科大学  医学部 基礎医学　解剖学    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Marked Changes in Lamellar Granule and Trans-Golgi Network Structure Occur during Epidermal Keratinocyte Differentiation.
掲載誌名	正式名：The Journal of investigative dermatology ISSNコード：15231747/0022202X
掲載区分	国外
巻・号・頁	139,pp.352-359
著者・共著者	Yamanishi H, Soma T, Kishimoto J, Hibino T, Ishida-Yamamoto A
発行年月	2019/02
概要	Epidermal lamellar granules transport various lipids, proteins, and protein inhibitors from the trans-Golgi network to the extracellular space, and play an important role in skin barrier formation. We elucidated the 3-dimensional structure of lamellar granules and the trans-Golgi network in normal human skin by focused ion beam scanning electron microscopy. Reconstructed focused ion beam scanning electron microscopy 3-dimensional images revealed that the overall lamellar granule structure changed from vesicular to reticular within the second layer of the stratum granulosum. Furthermore, the trans-Golgi network was well developed within this layer and spread through the cytoplasm with branched, tubular structures that connected to lamellar granules. Our study reveals the unique overall 3-dimensional structure of lamellar granules and the trans-Golgi network within the cells of the epidermis, and provides the basis for an understanding of the skin barrier formation.
researchmap用URL	https://www.sciencedirect.com/science/article/pii/S0022202X1832579X?via%3Dihub