オカザキ　トモコ   Tomoko Okazaki   岡崎　知子    所属   川崎医科大学  医学部 臨床医学　脳卒中医学    職種   期限付講師
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Multiple cerebral syphilitic gummas mimicking brain tumor in a non-HIV-infected patient: A case report.
掲載誌名	正式名：Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 略　 称：J Infect Chemother ISSNコード：14377780/1341321X
掲載区分	国外
巻・号・頁	25(3),pp.208-211
著者・共著者	Ryota Sasaki, Natsuki Tanaka, Tomoko Okazaki, Taiji Yonezawa
発行年月	2019/03
概要	We present a unique case of symptomatic early neurosyphilis in a non-HIV-infected patient. A 47-year-old man with a history of diabetes mellitus presented with generalized seizures. He did not manifest any neurological deficits. At first, multiple brain tumors were suspected based on findings from magnetic resonance imaging of the brain. However, serological and cerebrospinal fluid tests for syphilis yielded positive results, and the masses were reduced using amoxicillin. Multiple cerebral syphilitic gummas were therefore diagnosed. High-dose penicillin therapy was initiated and syphilitic gummas disappeared after five months. Treponema pallidum could invade the central nervous system at an early phase, and sometimes may be difficult to distinguish from malignant brain tumor. If intracranial lesions are identified in a syphilis-infected patient, cerebral syphilitic gumma should be considered as a differential diagnosis.
DOI	10.1016/j.jiac.2018.08.010
PMID	30249387