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モリヤ タクヤ
Takuya Moriya
森谷 卓也 所属 川崎医科大学 医学部 職種 学長付特任教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Pathological Study on the Expression of Vasohibins in Peripheral Artery Disease. |
| 掲載誌名 | 正式名：The Tohoku journal of experimental medicine 略 称：Tohoku J Exp Med ISSNコード：13493329/00408727 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 258(2),pp.121-128 |
| 著者・共著者 | Ryutaro Isoda, Ichiro Morita, Atsuhisa Ishida, Yuka Mikami, Yasumasa Monobe, Yasufumi Sato, Takuya Moriya |
| 発行年月 | 2022/09 |
| 概要 | Vasohibin-2 (VASH2) is a gene that promotes local angiogenesis. The tubulin carboxypeptidase activity of vasohibin causes detyrosination of alpha-tubulin and may play an important role in the regulation of various phenomena. Pathological and therapeutic angiogenesis are involved in atherosclerotic lesions. This study aimed to investigate whether the expression of VASH2 is associated with peripheral artery disease (PAD) in relation to angiogenesis, tubulin detyrosination, and severity of atherosclerotic lesions. An analysis of femoral and tibial arteries obtained from 86 patients with PAD or abdominal aortic aneurysm (AAA) was performed. The expressions of cluster of differentiation 31, VASH1, VASH2, and detyrosinated alpha-tubulin (DT-tubulin) were examined by immunohistochemistry, and their association with PAD was analyzed. The counts of VASH2 in the tunica media and adventitia in the tibial artery were significantly higher than those in the femoral artery in the PAD (P = 0.005 and P = 0.008, respectively) and AAA (P = 0.002 and P < 0.001, respectively) groups. In the tunica media and adventitia, VASH2 was significantly correlated with DT-tubulin. There was no significant difference in the expression of VASH2 and DT-tubulin in medial smooth muscle cells (McNemar test, P > 0.999). This study revealed the possible involvements of VASH2 in atherosclerosis by two methods-one maybe related to the progression of atherosclerosis by inducing angiogenesis and the second may be related to the decrease in arterial elasticity by increasing DT-tubulin in medial smooth muscle cells. |
| DOI | 10.1620/tjem.2022.J063 |
| PMID | 35922907 |