フククラ　ヨシヒコ   Yoshihiko Fukukura   福倉　良彦    所属   川崎医科大学  医学部 臨床医学　機能・代謝画像診断学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prognostic significance of extracellular volume fraction with equilibrium contrast-enhanced computed tomography for pancreatic neuroendocrine neoplasms.
掲載誌名	正式名：Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 略　 称：Pancreatology ISSNコード：14243911/14243903
掲載区分	国外
巻・号・頁	21(4),pp.779-786
著者・共著者	Hiromichi Iwaya, Yoshihiko Fukukura, Shinichi Hashimoto, Shiroh Tanoue, Machiko Kawahira, Makoto Hinokuchi, Toshihiro Fujita, Yuga Komaki, Shiho Arima, Fumisato Sasaki, Shuji Kanmura, Michiyo Higashi, Kiichi Tamada, Akio Ido
発行年月	2021/06
概要	BACKGROUND:/Objectives: Identifying reliable pretreatment imaging biomarkers for pancreatic neuroendocrine neoplasm (PanNEN) is a key imperative. Extracellular volume (ECV) fraction quantified with equilibrium contrast-enhanced CT can be easily integrated into routine examinations. This study aimed to determine whether ECV fraction with equilibrium contrast-enhanced computed tomography (CECT) could predict long-term outcomes in patients with PanNEN.METHODS:This study was a retrospective observational study of 80 patients pathologically diagnosed with PanNEN at a single institution. ECV fraction of the primary lesion was calculated using region-of-interest measurement within PanNEN and the aorta on unenhanced and equilibrium CECT. The impact of clinical factors and tumor ECV fraction on progression-free survival (PFS) and overall survival (OS) was assessed with univariate and multivariate analyses using Cox proportional hazards models. The correlation between WHO classification and tumor ECV fraction was evaluated using Kendall rank correlation coefficients.RESULTS:PFS and OS rates were estimated as 93.4% and 94.6%, 78.7% and 86.2%, 78.7% and 77.0%, and 78.7% and 66.6% at 1, 3, 5, and 10 years, respectively. Multivariate analysis revealed that Union for International Cancer Control (UICC) stage (hazard ratio [HR] = 3.95, P = 0.003), WHO classification (HR = 12.27, P = 0.003), and tumor ECV fraction (HR = 11.93, P = 0.039) were independent predictors of PFS. Patient age (HR = 1.11, P < 0.001), UICC stage (HR = 3.14, P = 0.001), and tumor ECV fraction (HR = 5.27, P = 0.024) were independent significant variables for predicting OS. Tumor ECV fraction had a weak inverse relationship with WHO classification (P = 0.045, τ = -0.178).CONCLUSIONS:ECV fraction determined by equilibrium CECT and UICC stage may predict survival in patients with PanNEN.
DOI	10.1016/j.pan.2021.02.020
PMID	33714670