フククラ　ヨシヒコ   Yoshihiko Fukukura   福倉　良彦    所属   川崎医科大学  医学部 臨床医学　機能・代謝画像診断学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	CT features of parathyroid carcinomas: comparison with benign parathyroid lesions.
掲載誌名	正式名：Japanese journal of radiology 略　 称：Jpn J Radiol ISSNコード：1867108X/18671071
掲載区分	国外
巻・号・頁	37(5),pp.380-389
著者・共著者	Koji Takumi, Yoshihiko Fukukura, Hiroto Hakamada, Hiroaki Nagano, Yuichi Kumagae, Hideo Arima, Akihiro Nakajo, Takashi Yoshiura
発行年月	2019/05
概要	PURPOSE:To describe CT features of parathyroid carcinomas (PCs) by comparison with benign parathyroid lesions (BPs).METHODS:This retrospective study comprised 82 patients with 76 BPs (62 adenomas and 14 hyperplastic lesions) and 6 PCs. CT features (size, short-to-long axis ratio, shape, peritumoral infiltration, homogeneity, calcification, attenuation values on unenhanced CT, and contrast enhancement during arterial and venous phases) were compared between PCs and BPs. The diagnostic performance of CT features for diagnosing PCs was calculated for these individual parameters.RESULTS:Short-to-long axis ratio was significantly larger in PCs (0.7 ± 0.1) than in BPs (0.5 ± 0.1, p = 0.004). Irregular shape (33%), the presence of peritumoral infiltration (50%), and calcification (33%) were significantly more common in PCs than BPs. The contrast enhancement value was significantly lower in PCs than BPs during arterial (p = 0.004) and venous phases (p = 0.044). The 100% sensitivity criterion for the short-to-long axis ratio (≥ 0.53), enhancement during arterial phase (≤ 56.6HU), and venous phase (≤ 59.5HU) yielded accuracies (62.1%, 71.9%, and 75.4%, respectively). Irregular shape, peritumoral infiltration, and calcification showed high specificity (98.7%) and accuracy (93.9%, 95.1%, and 93.9%, respectively).CONCLUSIONS:CT features of high short-to-long axis ratio, irregular shape, the presence of peritumoral infiltration and calcification, and low contrast enhancement may aid in distinguishing PCs from BPs.
DOI	10.1007/s11604-019-00825-3
PMID	30863971