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フククラ ヨシヒコ
Yoshihiko Fukukura
福倉 良彦 所属 川崎医科大学 医学部 臨床医学 機能・代謝画像診断学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Conspicuity of Malignant Liver Tumors on Diffusion-Weighted Imaging With Short tau Inversion Recovery After Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid Administration. |
| 掲載誌名 | 正式名：Journal of magnetic resonance imaging : JMRI 略 称：J Magn Reson Imaging ISSNコード：15222586/10531807 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 49(2),pp.565-573 |
| 著者・共著者 | Takashi Iwanaga, Yoshihiko Fukukura, Tomonori Saito, Masashi Sasaki, Yuichi Kumagae, Koji Takumi, Hiroto Hakamada, Takuro Fujisaki, Yasumasa Saigo, Takashi Yoshiura |
| 発行年月 | 2019/02 |
| 概要 | BACKGROUND:Diffusion-weighted imaging (DWI) has been used for the detection and characterization of liver tumors because it has excellent contrast resolution. DWI using short tau inversion recovery (STIR) can improve tumor-to-liver contrast after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration that shortens the T1 relaxation of liver parenchyma.PURPOSE:To quantitatively and qualitatively compare the conspicuity of malignant liver tumors on DWI after Gd-EOB-DTPA administration between STIR and chemical shift selective (CHESS) sequences.STUDY TYPE:Single-institution retrospective study.SUBJECTS:Fifty-seven patients with histologically confirmed malignant liver tumors were evaluated.FIELD STRENGTH/SEQUENCE:Low b-value DWIs with STIR and CHESS sequences 18-20 minutes after Gd-EOB-DTPA administration were acquired at 1.5T.ASSESSMENT:Tumor contrast-to-noise ratio (CNR) and visual grade of tumor conspicuity on DWI between STIR and CHESS sequences were compared.STATISTICAL TESTS:Paired Student's t-test and the Wilcoxon signed rank-test were applied. P < 0.05 was considered statistically significant.RESULTS:The mean tumor CNR and visual grade of tumor conspicuity on DWI were significantly higher for STIR than for CHESS (both P < 0.001). Regardless of the presence of chronic liver disease, the mean CNR (normal liver 33.5 ± 19.8 vs. 15.7 ± 12.2, P < 0.001; chronic liver disease 19.6 ± 11.0 vs. 9.2 ± 7.8, P < 0.001) and the visual conspicuity grade (normal liver 3.36 ± 0.64 vs. 2.56 ± 0.77, P < 0.001; chronic liver disease 2.94 ± 0.80 vs. 2.25 ± 0.84, P = 0.001) were significantly higher for STIR than for CHESS. Mean CNR and the visual conspicuity grade were also significantly higher for STIR than for CHESS in patients with hepatocellular carcinomas (CNR 18.1 ± 10.5 vs. 8.8 ± 7.2, P < 0.001; visual grade 2.88 ± 0.83 vs. 2.22 ± 0.87, P = 0.001) or metastases (CNR 35.0 ± 19.3 vs. 16.2 ± 13.1, P < 0.001; visual grade 3.45 ± 0.51 vs. 2.59 ± 0 |
| DOI | 10.1002/jmri.26196 |
| PMID | 30102432 |