フククラ　ヨシヒコ   Yoshihiko Fukukura   福倉　良彦    所属   川崎医科大学  医学部 臨床医学　機能・代謝画像診断学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Value of diffusion tensor imaging in differentiating malignant from benign parotid gland tumors.
掲載誌名	正式名：European journal of radiology 略　 称：Eur J Radiol ISSNコード：18727727/0720048X
掲載区分	国外
巻・号・頁	95,pp.249-256
著者・共著者	Koji Takumi, Yoshihiko Fukukura, Hiroto Hakamada, Junichi Ideue, Yuichi Kumagae, Takashi Yoshiura
発行年月	2017/10
概要	PURPOSE:To evaluate whether diffusion tensor imaging (DTI) can be used to differentiate malignant parotid gland tumors from the benign ones.MATERIALS AND METHODS:The study population comprised 59 parotid gland tumors (24 Warthin's tumors, 19 pleomorphic adenomas, seven other benign tumors, and nine malignant tumors). Single-shot echo-planar DTI was performed with motion-probing gradients along 30 noncollinear directions (b=1000s/mm2) at 3.0T. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values for benign and malignant tumors were compared using the Mann-Whitney U test. Receiver-operating characteristic (ROC) curve analysis was performed to assess the ability of the ADC and FA values to differentiate malignant tumors from the benign ones.RESULTS:ADC values showed no significant difference between malignant (0.93±0.21×10-3mm2/s) and benign tumors (1.19±0.50×10-3mm2/s) (p=0.225). FA values of malignant tumors were significantly higher than those of benign tumors (0.26±0.06 vs. 0.17±0.05, p<0.001). The area under the ROC curve of FA was significantly greater than that under the curve of ADC (0.884 vs. 0.628, p=0.010).CONCLUSIONS:DTI, particularly FA, can help differentiate malignant parotid gland tumors from the benign ones.
DOI	10.1016/j.ejrad.2017.08.013
PMID	28987676