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フククラ ヨシヒコ
Yoshihiko Fukukura
福倉 良彦 所属 川崎医科大学 医学部 臨床医学 機能・代謝画像診断学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Computed tomography and magnetic resonance imaging features of lipid-rich neuroendocrine tumors of the pancreas. |
| 掲載誌名 | 正式名：World journal of gastroenterology 略 称：World J Gastroenterol ISSNコード：22192840/10079327 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 21(34),pp.10008-10017 |
| 著者・共著者 | Yoshihiko Fukukura, Toshikazu Shindo, Michiyo Higashi, Koji Takumi, Tomokazu Umanodan, Tomohide Yoneyama, Takashi Yoshiura |
| 発行年月 | 2015/09 |
| 概要 | AIM:To clarify the computed tomography (CT) and magnetic resonance imaging (MRI) characteristics of lipid-rich pancreatic neuroendocrine tumors (PanNETs).METHODS:Enhanced CT and MRI performed before pancreatectomy in 29 patients with 34 histologically-confirmed PanNETs was retrospectively reviewed. Tumor attenuation on CT and signal intensities on conventional (T1- and T2-weighted) and chemical shift MRI were qualitatively analyzed and compared alongside adipose differentiation-related protein (ADRP) immunostaining (ADRP-positive: lipid-rich; ADRP-negative: non-lipid-rich) results using Fisher's exact test or the Mann-Whitney U test. Signal intensity index on chemical shift MRI was quantitatively assessed.RESULTS:There were 15 lipid-rich PanNETs (44.1%) in 12 patients (41.4%). Tumor attenuation during the early, portal venous, and delayed phases of enhanced CT (P = 0.888, 0.443, and 0.359, respectively) and signal intensities on conventional MRI (P = 0.698 and 0.798, respectively) were not significantly different between lipid-rich and non-lipid-rich PanNETs. Four of the 15 lipid-rich PanNETs exhibited high signal intensity on subtraction chemical shift MRI, and the association of high signal intensity on subtraction imaging with lipid-rich PanNETs was significant (4 of 15 lipid-rich PanNETs, 26.73%, vs 0 of 19 non-lipid-rich PanNETs, 0%, P = 0.029). Lipid-rich PanNETs showed a significantly higher signal intensity index than non-lipid-rich PanNETs (0.6% ± 14.1% vs -10.4% ± 14.4%, P = 0.004). Eight of 15 lipid-rich PanNETs, vs 0 of 19 non-lipid-rich PanNETs, had positive signal intensity index values in concordance with lipid contents.CONCLUSION:CT contrast enhancement and conventional MR signal intensities are similar in lipid-rich and non-lipid-rich PanNETs. Chemical shift MRI can demonstrate cytoplasmic lipids in PanNETs. |
| DOI | 10.3748/wjg.v21.i34.10008 |
| PMID | 26379406 |