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フククラ ヨシヒコ
Yoshihiko Fukukura
福倉 良彦 所属 川崎医科大学 医学部 臨床医学 機能・代謝画像診断学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma. |
| 掲載誌名 | 正式名：Neuroradiology 略 称：Neuroradiology ISSNコード：14321920/00283940 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 56(7),pp.525-534 |
| 著者・共著者 | Ryuji Awa, Francia Campos, Kazunori Arita, Kazuhiko Sugiyama, Atsushi Tominaga, Kaoru Kurisu, Fumiyuki Yamasaki, Prasanna Karki, Hiroshi Tokimura, Yoshihiko Fukukura, Yukihiko Fujii, Ryosuke Hanaya, Tatsuki Oyoshi, Hirofumi Hirano |
| 発行年月 | 2014/07 |
| 概要 | INTRODUCTION:Our study aimed to elucidate the imaging features for the differentiation of pineal germinoma and other pineal region tumors.METHODS:Image data sets of computed tomographic (CT) scan and magnetic resonance imaging (MRI) data of 93 pineal region tumors including 33 germinomas, 30 nongerminomatous germ cell tumors (NGGCTs), 20 pineal parenchymal tumors (PPTs), and 10 miscellaneous tumors of pineal region were reviewed. Imaging features on CT and MRI were qualitatively assessed by three readers. To know the reasons for morphological differences between germinomas and NGGCTs, histological investigation was done.RESULTS:Localized calcification was seen in more than 70 % of germ cells tumors (GCTs: germinomas and NGGCTs) while it was scattered in more than half of PPTs. Cystic components in tumors were most frequent in NGGCTs (62 %). Multiplicity of lesion was restricted to GCTs: 39.4 % in germinoma and 10.0 % in NGGCTs. Thick peritumoral edema was more frequent in germinoma than in NGGCT: 40.6 vs. 14.8 % (p=0.0433, Fisher's test). Bithalamic extension of tumor was seen in 78.8 % of germinomas. It was significantly rare in other groups of tumors (p<0.0001, Fisher's test). The relative collagen amount per unit area was significantly lower in germinoma than in NGGCTs.CONCLUSION:By paying attention to characteristic features as bithalamic extension, thick peritumoral edema, calcification pattern, multiplicity, and their combination, the preoperative differential diagnosis of pineal germinoma will become more accurate. |
| DOI | 10.1007/s00234-014-1369-4 |
| PMID | 24777305 |