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フククラ ヨシヒコ
Yoshihiko Fukukura
福倉 良彦 所属 川崎医科大学 医学部 臨床医学 機能・代謝画像診断学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Contrast-enhanced CT and diffusion-weighted MR imaging: performance as a prognostic factor in patients with pancreatic ductal adenocarcinoma. |
| 掲載誌名 | 正式名：European journal of radiology 略 称：Eur J Radiol ISSNコード：18727727/0720048X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 83(4),pp.612-619 |
| 著者・共著者 | Yoshihiko Fukukura, Koji Takumi, Michiyo Higashi, Hiroyuki Shinchi, Kiyohisa Kamimura, Tomohide Yoneyama, Akihiro Tateyama |
| 発行年月 | 2014/04 |
| 概要 | OBJECTIVE:To determine whether contrast enhancement of CT and apparent diffusion coefficient on diffusion-weighted MR imaging are important parameters that can predict outcomes for patients with pancreatic ductal adenocarcinoma.MATERIALS AND METHODS:Ninety-two patients with histologically confirmed pancreatic ductal adenocarcinoma who underwent quadriphasic CT (including unenhanced, pancreatic parenchymal, portal venous and delayed phases) and fat-suppressed single-shot echo-planar diffusion-weighted MR imaging at 3.0 T were retrospectively analyzed to investigate prognostic factors. Overall survival curves were drawn using the Kaplan-Meier method. Effects on survival of variables including age, sex, tumor location, tumor size, TNM stage, carbohydrate antigen 19-9, carcinoembryonic antigen, treatment, tumor contrast enhancement and apparent diffusion coefficient values were analyzed in univariate analysis using the log-rank test. Variables were analyzed in multivariate analyses using the Cox proportional hazards regression model.RESULTS:Median survival for the entire patient population was 18.2 months. Higher contrast enhancement during all phases was associated with significantly longer overall survival (P<0.001 for all phases). The difference in overall survival between groups divided by median apparent diffusion coefficient value was not significant (P=0.672). TNM stage (P=0.026) and tumor contrast enhancement on CT (P=0.027) were significantly related to survival in multivariate analysis.CONCLUSIONS:Poor enhancement of pancreatic adenocarcinomas on enhanced CT is associated with reduced patient survival. |
| DOI | 10.1016/j.ejrad.2013.12.016 |
| PMID | 24418286 |