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フククラ ヨシヒコ
Yoshihiko Fukukura
福倉 良彦 所属 川崎医科大学 医学部 臨床医学 機能・代謝画像診断学 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function. |
| 掲載誌名 | 正式名：European radiology 略 称：Eur Radiol ISSNコード：14321084/09387994 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 24(4),pp.857-865 |
| 著者・共著者 | Tomohide Yoneyama, Yoshihiko Fukukura, Kiyohisa Kamimura, Koji Takumi, Aya Umanodan, Shinichi Ueno, Masayuki Nakajo |
| 発行年月 | 2014/04 |
| 概要 | OBJECTIVE:We aimed to develop and assess the efficacy of a liver function index that combines liver enhancement and liver volume to standard liver volume (LV/SLV) ratio on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI.METHODS:In all, 111 patients underwent a Gd-EOB-DTPA-enhanced MRI, including T1 mapping, before and 20 min after Gd-EOB-DTPA administration. We calculated the following Gd-EOB-DTPA-enhanced MRI-based liver function indices: relative enhancement of the liver, corrected enhancement of the liver-to-spleen ratio, LSC_N20, increase rate of the liver-to-muscle ratio, reduction rate of T1 relaxation time of the liver, ΔR1 of the liver and K Hep; the indices were multiplied by the LV/SLV ratio. We calculated the correlations between an indocyanine green (ICG) clearance and the Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio, by using Pearson correlation analysis.RESULTS:There were significant correlations between all Gd-EOB-DTPA-enhanced MRI-based liver function indices and ICG clearance (r = -0.354 to -0.574, P < 0.001). All Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio (r = -0.394 to -0.700, P < 0.001) were more strongly correlated with the ICG clearance than those without multiplication by the LV/SLV ratio.CONCLUSIONS:Gd-EOB-DTPA-enhanced MRI-based liver function indices that combine liver enhancement and the LV/SLV ratio may more reliably estimate liver function.KEY POINTS:• Gd-EOB-DTPA-enhanced MRI is useful for assessing liver function. • Liver enhancement on Gd-EOB-DTPA-enhanced MRI correlates with indocyanine green (ICG) clearance. • Liver volume to standard liver volume (LV/SLV) ratio correlates with ICG clearance. • Liver enhancement and LV/SLV ratio help to estimate liver function. |
| DOI | 10.1007/s00330-013-3086-5 |
| PMID | 24356768 |