フククラ　ヨシヒコ   Yoshihiko Fukukura   福倉　良彦    所属   川崎医科大学  医学部 臨床医学　機能・代謝画像診断学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A prospective evaluation of how a low level of response to alcohol predicts later heavy drinking and alcohol problems.
掲載誌名	正式名：The American journal of drug and alcohol abuse 略　 称：Am J Drug Alcohol Abuse ISSNコード：10979891/00952990
掲載区分	国外
巻・号・頁	37(6),pp.479-486
著者・共著者	Marc A Schuckit, Tom L Smith, Ryan S Trim, Rhonda C Allen, Tsutomu Fukukura, Emily E Knight, Erin M Cesario, Sara A Kreikebaum
発行年月	2011/11
概要	BACKGROUND AND OBJECTIVES:Evaluations of how a genetically influenced characteristic, such as the low level of response (a low LR) to alcohol, relates to later heavy drinking and alcohol problems usually include environmental contributors. The best way to understand how LR works in the context of these additional characteristics is to study the process prospectively, but such analyses tend to be complex and the papers are sometimes cluttered with jargon. This report attempts to offer a more straightforward description of the results from such a prospective model of how a lower LR at age 20 relates to alcohol outcomes at age 40.METHODS:A structural equation model of LR at age ∼20, outcomes of heavy drinking and problems at age ∼40, and additional characteristics at age ∼35 were tested in 378 men from the San Diego Prospective Study.RESULTS:The results support both direct effects of age-20 LR on age-40 heavy drinking and alcohol problems, as well as indirect effects of LR through characteristics of these men at age 35. The latter include using alcohol to cope with stress and heavier drinking among peers.CONCLUSIONS:A low LR to alcohol is an example of how both genes and environment can contribute to the risk for adverse alcohol outcomes. The identification of mechanisms through which LR impacts on later heavy drinking and problems can be approached in cross-sectional studies, but those may not be as sensitive as longitudinal models for identifying additional potential mediators of the LR-to-outcome relationship.
DOI	10.3109/00952990.2011.598590
PMID	21797810